(Q35033329)

5 August 2017

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title

Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton (English)

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5 August 2017

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Jeffrey R Peterson

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5 August 2017

Timothy J Mitchison

series ordinal

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5 August 2017

publication date

1 December 2002

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5 August 2017

published in

Chemistry and Biology

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

1275-1285

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THE CHROMOSOME NUMBER OF MAN

5 August 2017

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7 January 2021

The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus

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Isolation of a protein subunit from microtubules

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Colchicine-binding protein of mammalian brain and its relation to microtubules

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7 January 2021

Amino-acid composition of "Tubulin" constituting microtubules of sperm flagella

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7 January 2021

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

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7 January 2021

Taxol: Twenty Years Later, the Story Unfolds

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7 January 2021

Promotion of microtubule assembly in vitro by taxol

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7 January 2021

The effect of taxol on living eggs ofXenopus laevis

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Taxol stabilizes microtubules in mouse fibroblast cells

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A taxol-dependent procedure for the isolation of microtubules and microtubule-associated proteins (MAPs).

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7 January 2021

Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility

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7 January 2021

Interaction of oncodazole (R 17934), a new anti-tumoral drug, with rat brain tubulin

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7 January 2021

Microtubules and the organization of the Golgi complex

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7 January 2021

Effect of microtubule inhibitors on invasion and on related activities of tumor cells.

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7 January 2021

ON THE ACTION OF COLCHICINE, THE MELANOCYTE MODEL

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7 January 2021

Microtubules and the movement of melanin granules in frog dermal melanocytes

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7 January 2021

The mechanism of microtubule-dependent movement of pigment granules in teleost chromatophores

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7 January 2021

Cell line-specific differences in the control of cell cycle progression in the absence of mitosis

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7 January 2021

Dominoes and clocks: the union of two views of the cell cycle

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7 January 2021

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

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7 January 2021

Feedback control of mitosis in budding yeast

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7 January 2021

Role of chance observations in chemotherapy: Vinca rosea

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7 January 2021

The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics

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7 January 2021

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

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7 January 2021

Chemical Biology of Epothilones

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7 January 2021

Microtubule-stabilizing agents: a growing class of important anticancer drugs

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7 January 2021

Chemical synthesis and biological properties of pyridine epothilones

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7 January 2021

Recent developments in the chemistry, biology and medicine of the epothilones

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7 January 2021

Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle

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7 January 2021

Recent advances in the chemistry of taxol

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7 January 2021

Effects of Cytochalasins on Mammalian Cells

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7 January 2021

Haptotaxis and the Mechanism of Cell Motility

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7 January 2021

On the mechanism of astral cleavage

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7 January 2021

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7 January 2021

Cytoplasmic fibrils in living cultured cells. A light and electron microscope study

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7 January 2021

Formation of arrowhead complexes with heavy meromyosin in a variety of cell types

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7 January 2021

Ultrastructural characterization of F-actin isolated from Acanthamoeba castellanii and identification of cytoplasmic filaments as F-actin by reaction with rabbit heavy meromyosin

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7 January 2021

Actin in the Brush-Border of Epithelial Cells of the Chicken Intestine

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7 January 2021

Electron microscope observations on actomyosin and actin preparations from Physarum polycephalum, and on their interaction with heavy meromyosin subfragment I from muscle myosin

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7 January 2021

Filaments of Amoeba proteus. II. Binding of heavy meromyosin by thin filaments in motile cytoplasmic extracts

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7 January 2021

Axon growth: roles of microfilaments and microtubules

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7 January 2021

Effects of cytochalasin B upon microfilaments involved in morphogenesis of salivary epithelium

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7 January 2021

Cytochalasin B: effects upon microfilaments involved in morphogenesis of estrogen-induced glands of oviduct

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7 January 2021

Cytochalasin B, its interaction with actin and actomyosin from muscle (cell movement-microfilaments-rabbit striated muscle).

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7 January 2021

Über die Giftstoffe des Knollenblätterpilzes. IV

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7 January 2021

The toxic peptides from Amanita mushrooms

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7 January 2021

In-vitro effect of phalloidin on a plasma membrane preparation from rat liver

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7 January 2021

Interaction of phalloidin with actin

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7 January 2021

Fluorescent phallotoxin, a tool for the visualization of cellular actin

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7 January 2021

Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide

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7 January 2021

Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells

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7 January 2021

Inhibition of actin polymerization by latrunculin A.

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7 January 2021

Lethal disruption of the yeast actin gene by integrative DNA transformation.

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7 January 2021

Phenotypic analysis of temperature-sensitive yeast actin mutants

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7 January 2021

High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A.

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7 January 2021

Actin from Saccharomyces cerevisiae

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7 January 2021

Role of actin and Myo2p in polarized secretion and growth of Saccharomyces cerevisiae.

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7 January 2021

The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle

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7 January 2021

Endocytosis and the development of cell polarity in yeast require a dynamic F-actin cytoskeleton.

1 reference

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7 January 2021

Latrunculins--novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D.

1 reference

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7 January 2021

Latrunculin alters the actin-monomer subunit interface to prevent polymerization

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900284-3

7 January 2021

Cytochalasin B: inhibition of D-2-deoxyglucose transport into leukocytes and fibroblasts

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7 January 2021

Effects of cytochalasins B and D on alloxan inhibition of insulin release

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7 January 2021

The crystal structure of uncomplexed actin in the ADP state

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7 January 2021

Atomic structure of the actin:DNase I complex

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7 January 2021

Structure of gelsolin segment 1-actin complex and the mechanism of filament severing

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7 January 2021

Domain Movement in Gelsolin: A Calcium-Activated Switch

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7 January 2021

The structure of crystalline profilin-beta-actin

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7 January 2021

Structure of the alpha beta tubulin dimer by electron crystallography

1 reference

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7 January 2021

The effects of Colcemid inhibition and reversal on the fine structure of the mitotic apparatus of Chinese hamster cells in vitro

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7 January 2021

Cytoplasmic microtubules in tissue culture cells appear to grow from an organizing structure towards the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900284-3

7 January 2021

The attachment of kinetochores to the pro-metaphase spindle in PtK1 cells. Recovery from low temperature treatment

1 reference

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7 January 2021

Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone

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7 January 2021

Actin dynamics in vivo.

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7 January 2021

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

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7 January 2021

Mitotic spindle organization by a plus-end-directed microtubule motor

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7 January 2021

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

1 reference

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7 January 2021

Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix

1 reference

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7 January 2021

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

1 reference

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7 January 2021

A small-molecule inhibitor of skeletal muscle myosin II.

1 reference

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7 January 2021

Myosins: a diverse superfamily

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7 January 2021

Unnatural ligands for engineered proteins: new tools for chemical genetics

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7 January 2021

Allele-specific activators and inhibitors for kinesin

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7 January 2021

A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.

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7 January 2021

Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N(6)-modified ADP analogs

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7 January 2021

A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions

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7 January 2021

How WASP regulates actin polymerization

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900284-3

7 January 2021

Recent advances in chemical approaches to the study of biological systems

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7 January 2021

Genomic expression programs in the response of yeast cells to environmental changes

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900284-3

7 January 2021

Remodeling of yeast genome expression in response to environmental changes

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https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900284-3

7 January 2021

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2802%2900284-3

7 January 2021

Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin

1 reference

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7 January 2021

10.1016/S1074-5521(02)00284-3

Identifiers

DOI

1 reference

5 August 2017

1 reference