(Q34707942)

4 August 2017

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title

Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression (English)

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alternative mRNA splicing, via spliceosome

4 August 2017

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Ryszard Kole

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4 August 2017

author name string

Danielle R Mercatante

series ordinal

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4 August 2017

language of work or name

English

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publication date

1 July 2002

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Biochimica et Biophysica Acta

4 August 2017

published in

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4 August 2017

volume

1587

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4 August 2017

issue

2-3

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4 August 2017

page(s)

126-132

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RNA processing and the evolution of eukaryotes

4 August 2017

cites work

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7 January 2021

Alternative splicing of pre-mRNA: developmental consequences and mechanisms of regulation

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7 January 2021

Regulation of pre-mRNA splicing in metazoa

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7 January 2021

The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: causes and consequences

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7 January 2021

Two novel mutations affecting mRNA splicing of the neurofibromatosis type 1 (NF1) gene

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7 January 2021

The splice of life: alternative splicing and neurological disease

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7 January 2021

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

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7 January 2021

Modification of alternative splicing by antisense oligonucleotides as a potential chemotherapy for cancer and other diseases

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7 January 2021

Modification of alternative splicing pathways as a potential approach to chemotherapy

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7 January 2021

Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients

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7 January 2021

Antisense oligonucleotides with different backbones. Modification of splicing pathways and efficacy of uptake

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7 January 2021

Repair of thalassemic human beta-globin mRNA in mammalian cells by antisense oligonucleotides

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7 January 2021

Sensitivity of splice sites to antisense oligonucleotides in vivo.

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7 January 2021

Antisense oligonucleotides and RNAs as modulators of pre-mRNA splicing

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7 January 2021

Correction of aberrant splicing of the cystic fibrosis transmembrane conductance regulator (CFTR) gene by antisense oligonucleotides

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7 January 2021

Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides.

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7 January 2021

Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides

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7 January 2021

Modification of alternative splicing of Bcl-x pre-mRNA in prostate and breast cancer cells. analysis of apoptosis and cell death.

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7 January 2021

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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7 January 2021

Expression of apoptosis-regulatory genes in lung tumour cell lines: relationship to p53 expression and relevance to acquired drug resistance

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7 January 2021

Overexpression of Bcl-x(L) promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model

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7 January 2021

Bcl-xL modulates apoptosis induced by anticancer drugs and delays DEVDase and DNA fragmentation-promoting activities

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7 January 2021

Antisense DNAs as multisite genomic modulators identified by DNA microarray

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7 January 2021

Molecular profiling of human cancer

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7 January 2021

Applications of microarray technology in breast cancer research

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7 January 2021

Genes regulated in human breast cancer cells overexpressing manganese-containing superoxide dismutase

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7 January 2021

Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells

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7 January 2021

Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis

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7 January 2021

Effector genes altered in MCF-7 human breast cancer cells after exposure to fractionated ionizing radiation

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7 January 2021

Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment

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7 January 2021

A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes

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7 January 2021

An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons

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7 January 2021

Sequestration and inhibition of Daxx-mediated transcriptional repression by PML

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7 January 2021

Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).

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7 January 2021

Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation.

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7 January 2021

Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers

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7 January 2021

Antisense therapy in oncology: new hope for an old idea?

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7 January 2021

Clinical studies of antisense therapy in cancer

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7 January 2021

Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas.

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7 January 2021

Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas.

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7 January 2021

Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer

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7 January 2021

Alternative splicing of fibroblast growth factor receptors in human prostate cancer

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7 January 2021

An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein

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7 January 2021

Identification of a novel alternative splicing of human FGF receptor 4: soluble-form splice variant expressed in human gastrointestinal epithelial cells.

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7 January 2021

The normal structure and function of CD44 and its role in neoplasia

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7 January 2021

Adhesion proteins in the biology of breast cancer: contribution of CD44.

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7 January 2021

Stage-specific alternative cplicing of CD44 and alpha 6 beta 1 integrin in colorectal tumorigenesis

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7 January 2021

Human neuroblastomas with unfavorable biologies express high levels of brain-derived neurotrophic factor mRNA and a variety of its variants

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7 January 2021

Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation

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7 January 2021

A novel splice variant of HER2 with increased transformation activity

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7 January 2021

Alternative splicing is associated with decreased expression of the redox proto-oncogene thioredoxin-1 in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia

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7 January 2021

Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines

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7 January 2021

Characterization of Bax-sigma, a cell death-inducing isoform of Bax

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https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

Overexpression of bax enhances the radiation sensitivity in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

The FHIT gene is alternatively spliced in normal kidney and renal cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

Differential expression of p73 splice variants and protein in benign and malignant ovarian tumours

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https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

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https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

The Wilms tumour gene WT1 in leukaemia

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https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

Analysis of native WT1 protein from frozen human kidney and Wilms' tumors

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7 January 2021

Expression profiles of BRCA1 splice variants in asynchronous and in G1/S synchronized tumor cell lines

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7 January 2021

Reduced expression levels of nucleotide excision repair genes in lung cancer: a case-control analysis

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https://api.crossref.org/works/10.1016%2FS0925-4439%2802%2900075-3

7 January 2021

The human XPG gene: gene architecture, alternative splicing and single nucleotide polymorphisms

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7 January 2021

10.1016/S0925-4439(02)00075-3

Identifiers

DOI

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4 August 2017

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