(Q34703711)

4 August 2017

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title

The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections (English)

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4 August 2017

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systemic immune response

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Dominique Ferrandon

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4 August 2017

Jean-Luc Imler

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4 August 2017

Charles Hetru

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4 August 2017

Jules A Hoffmann

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4 August 2017

publication date

1 November 2007

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Nature Reviews Immunology

4 August 2017

published in

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

862-874

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Sequence and specificity of two antibacterial proteins involved in insect immunity

4 August 2017

cites work

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Antimicrobial peptides in insects; structure and function

31 March 2020

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The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

31 March 2020

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Dorsoventral axis formation in the Drosophila embryo--shaping and transducing a morphogen gradient

31 March 2020

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The immune response of Drosophila

31 March 2020

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Beta-1,3-glucan receptor and peptidoglycan receptor are present as separate entities within insect prophenoloxidase activating system

31 March 2020

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The Drosophila immune system detects bacteria through specific peptidoglycan recognition

31 March 2020

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Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway

31 March 2020

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Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors.

31 March 2020

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Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

31 March 2020

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A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster

31 March 2020

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A scavenger function for a Drosophila peptidoglycan recognition protein.

31 March 2020

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PGRP-SB1: an N-acetylmuramoyl L-alanine amidase with antibacterial activity.

31 March 2020

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Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster

31 March 2020

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The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

31 March 2020

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Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila

31 March 2020

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Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae

31 March 2020

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Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity

31 March 2020

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PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan.

31 March 2020

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Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway

31 March 2020

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Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro

31 March 2020

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Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition

31 March 2020

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Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs).

31 March 2020

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Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins

31 March 2020

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Structure of Tracheal Cytotoxin in Complex with a Heterodimeric Pattern-Recognition Receptor

31 March 2020

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The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection.

31 March 2020

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Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2.

31 March 2020

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The Toll and Imd pathways are the major regulators of the immune response in Drosophila

31 March 2020

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Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body

31 March 2020

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Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein

31 March 2020

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Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria

31 March 2020

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Dual activation of the Drosophila toll pathway by two pattern recognition receptors

31 March 2020

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Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori

31 March 2020

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A pattern-recognition protein for beta-1,3-glucan. The binding domain and the cDNA cloning of beta-1,3-glucan recognition protein from the silkworm, Bombyx mori

31 March 2020

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A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity

31 March 2020

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Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA

31 March 2020

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Requirements of peptidoglycan structure that allow detection by the Drosophila Toll pathway

31 March 2020

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The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila

31 March 2020

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Activation of Drosophila Toll during fungal infection by a blood serine protease

31 March 2020

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31 March 2020

The plant immune system

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Structure and function of Toll receptors and their ligands

31 March 2020

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Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling

31 March 2020

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Multimerization and interaction of Toll and Spätzle in Drosophila

31 March 2020

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New insights into Drosophila larval haemocyte functions through genome-wide analysis

31 March 2020

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31 March 2020

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A family of proteins related to Spätzle, the toll receptor ligand, are encoded in the Drosophila genome.

31 March 2020

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Tissue and stage-specific expression of the Tolls in Drosophila embryos.

31 March 2020

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Genomic insights into the immune system of the sea urchin

31 March 2020

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Proteolytic processing of the Drosophila Spätzle protein by easter generates a dimeric NGF-like molecule with ventralising activity

31 March 2020

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A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity

31 March 2020

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Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation

31 March 2020

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Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor

31 March 2020

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Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections

31 March 2020

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Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning

31 March 2020

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Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo

31 March 2020

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Cactus protein degradation mediates Drosophila dorsal-ventral signaling

31 March 2020

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The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase.

31 March 2020

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Role of Drosophila IKK gamma in a toll-independent antibacterial immune response

31 March 2020

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Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo.

31 March 2020

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A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal

31 March 2020

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Innate immune recognition of viral infection

31 March 2020

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Cactus-independent regulation of Dorsal nuclear import by the ventral signal.

31 March 2020

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Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo

31 March 2020

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WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity

31 March 2020

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A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense

31 March 2020

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Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis

31 March 2020

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Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor

31 March 2020

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Relish, a central factor in the control of humoral but not cellular immunity in Drosophila

31 March 2020

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A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity

31 March 2020

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Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage

31 March 2020

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Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses

31 March 2020

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Immune Activation of NF-κB and JNK Requires Drosophila TAK1

31 March 2020

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A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component

31 March 2020

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An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila.

31 March 2020

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Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

31 March 2020

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Ubiquitin signalling in the NF-kappaB pathway

31 March 2020

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The role of ubiquitination in Drosophila innate immunity.

31 March 2020

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The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection

31 March 2020

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The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis

31 March 2020

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Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults

31 March 2020

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The Drosophila caspase Dredd is required to resist gram-negative bacterial infection

31 March 2020

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The Drosophila immune defense against gram-negative infection requires the death protein dFADD.

31 March 2020

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Caspase-mediated processing of the Drosophila NF-kappaB factor Relish

31 March 2020

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Sequential activation of signaling pathways during innate immune responses in Drosophila.

31 March 2020

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Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila

31 March 2020

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Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway

31 March 2020

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Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules.

31 March 2020

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Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways

31 March 2020

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A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade

31 March 2020

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Caspar, a suppressor of antibacterial immunity in Drosophila

31 March 2020

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A kappaB sequence code for pathway-specific innate immune responses

31 March 2020

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Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster

31 March 2020

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Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants

31 March 2020

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Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model

31 March 2020

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An essential complementary role of NF-kappaB pathway to microbicidal oxidants in Drosophila gut immunity

31 March 2020

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Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene

31 March 2020

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Peptidomic and proteomic analyses of the systemic immune response of Drosophila

31 March 2020

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A genome-wide analysis of immune responses in Drosophila

31 March 2020

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Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays

31 March 2020

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Proteomics of the Drosophila immune response

31 March 2020

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An immune-responsive Serpin regulates the melanization cascade in Drosophila

31 March 2020

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A serpin mutant links Toll activation to melanization in the host defence of Drosophila

31 March 2020

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An antioxidant system required for host protection against gut infection in Drosophila.

31 March 2020

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Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression

31 March 2020

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Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species

31 March 2020

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Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.

31 March 2020

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Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes.

31 March 2020

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Extensive diversity of Ig-superfamily proteins in the immune system of insects

31 March 2020

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A specific primed immune response in Drosophila is dependent on phagocytes

31 March 2020

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Genetic basis of natural variation in D. melanogaster antibacterial immunity

31 March 2020

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The clip-domain family of serine proteinases in arthropods

31 March 2020

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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

31 March 2020

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Rel/NF-kappaB double mutants reveal that cellular immunity is central to Drosophila host defense

31 March 2020

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Drosophila genome-wide RNAi screens: are they delivering the promise?

31 March 2020

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Genomic dissection of microbial pathogenesis in cultured Drosophila cells.

31 March 2020

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A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway

31 March 2020

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The imd gene is required for local Cecropin expression in Drosophila barrier epithelia

31 March 2020

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A direct role for dual oxidase in Drosophila gut immunity

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2194

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4 August 2017

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