(Q34667599)

3 August 2017

title

Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1 (English)

1 reference

3 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21030561

16 August 2024

Mien V. Hoang

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21030561

16 August 2024

Janice A. Nagy

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21030561

16 August 2024

Donald R. Senger

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21030561

16 August 2024

language of work or name

English

0 references

publication date

28 October 2010

1 reference

full work available at URL

3 August 2017

http://www.bloodjournal.org/content/117/5/1751.full.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21030561

http://www.bloodjournal.org/cgi/content/abstract/117/5/1751

16 August 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21030561

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21030561/?tool=EBI

16 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21030561

https://europepmc.org/articles/PMC3056599

16 August 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21030561

https://doi.org/10.1182/blood-2010-05-286831

16 August 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21030561

http://ashpublications.org/blood/article-pdf/117/5/1751/1343810/zh800511001751.pdf

16 August 2024

file format

Portable Document Format

1 reference

10.1182/BLOOD-2010-05-286831

Crossref

DOI

https://api.crossref.org/works/10.1182/BLOOD-2010-05-286831

16 August 2024

1 reference

3 August 2017

volume

117

1 reference

3 August 2017

1 reference

3 August 2017

page(s)

1751-1760

1 reference

describes a project that uses

3 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3056599/fullTextXML

inferred from PubMed Central ID database lookup

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7 July 2018

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VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2

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Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo

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7 July 2018

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Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity

7 July 2018

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Blood flow remodels growing vasculature during vascular endothelial growth factor gene therapy and determines between capillary arterialization and sprouting angiogenesis

7 July 2018

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VEGF-A, cytoskeletal dynamics, and the pathological vascular phenotype

7 July 2018

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A Rac switch regulates random versus directionally persistent cell migration

7 July 2018

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S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate

7 July 2018

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Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase

7 July 2018

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Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization

7 July 2018

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7 July 2018

1 reference

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Rho activity critically and selectively regulates endothelial cell organization during angiogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Requirement of Rac activity for maintenance of capillary endothelial barrier properties

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network. Adherens junctions and myosin light chain as targets of Rac1 and RhoA.

7 July 2018

1 reference

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Rac regulates endothelial morphogenesis and capillary assembly

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta

7 July 2018

1 reference

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Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Complexation of retrovirus with cationic and anionic polymers increases the efficiency of gene transfer.

7 July 2018

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Assessment of risks associated with cardiovascular gene therapy in human subjects

7 July 2018

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Coadministration of angiopoietin-1 and vascular endothelial growth factor enhances collateral vascularization

7 July 2018

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VEGF gene delivery to myocardium: deleterious effects of unregulated expression

7 July 2018

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Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

7 July 2018

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Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

7 July 2018

1 reference

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Activation of Rac and Cdc42 by integrins mediates cell spreading

7 July 2018

1 reference

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Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins

7 July 2018

1 reference

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Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

7 July 2018

1 reference

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Between molecules and morphology. Extracellular matrix and creation of vascular form.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

An essential role for Rac1 in endothelial cell function and vascular development.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Permeability properties of tumor surrogate blood vessels induced by VEGF-A.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Collagen I initiates endothelial cell morphogenesis by inducing actin polymerization through suppression of cyclic AMP and protein kinase A.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Rho and Rac but not Cdc42 regulate endothelial cell permeability.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Vasculogenesis in the day 6.5 to 9.5 mouse embryo.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3056599

Small GTP-Binding Protein Rac Is an Essential Mediator of Vascular Endothelial Growth Factor-Induced Endothelial Fenestrations and Vascular Permeability

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21030561

12 December 2020

inferred from PubMed ID database lookup

An alpha 2 beta 1 integrin-dependent pinocytic mechanism involving intracellular vacuole formation and coalescence regulates capillary lumen and tube formation in three-dimensional collagen matrix

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21030561

12 December 2020

inferred from PubMed ID database lookup

In vivo and in vitro models of Mammalian angiogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21030561

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1182/BLOOD-2010-05-286831

1 reference

3 August 2017

1 reference

3 August 2017

1 reference