(Q34635871)

3 August 2017

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title

Interaction sites on human IgG-Fc for FcgammaR: current models (English)

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3 August 2017

Roy Jefferis

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3 August 2017

John Lund

series ordinal

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3 August 2017

publication date

1 June 2002

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3 August 2017

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3 August 2017

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3 August 2017

issue

1-2

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3 August 2017

page(s)

57-65

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IgG-Fc-mediated effector functions: molecular definition of interaction sites for effector ligands and the role of glycosylation

3 August 2017

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Molecular basis of Fc receptor function

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Human antibodies as next generation therapeutics

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Multiple roles for the major histocompatibility complex class I- related receptor FcRn

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Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein

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Remodelling the oligosaccharide of human IgG antibodies: effects on biological activities

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The IgG Subclass Pattern of Complement Activation Depends on Epitope Density and Antibody and Complement Concentration

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Neutrophil Fc gamma and complement receptors involved in binding soluble IgG immune complexes and in specific granule release induced by soluble IgG immune complexes

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Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution

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Anatomy of the antibody molecule

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Comparison of intact antibody structures and the implications for effector function.

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Structure of human IgM rheumatoid factor Fab bound to its autoantigen IgG Fc reveals a novel topology of antibody-antigen interaction

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A protein structural change in aglycosylated IgG3 correlates with loss of huFc gamma R1 and huFc gamma R111 binding and/or activation

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The protein trinity--linking function and disorder.

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7 January 2021

Glycosylation of human IgG-Fc: influences on structure revealed by differential scanning micro-calorimetry

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7 January 2021

The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms.

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Dynamics of the carbohydrate chains attached to the Fc portion of immunoglobulin G as studied by NMR spectroscopy assisted by selective 13C labeling of the glycans

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Variations in oligosaccharide-protein interactions in immunoglobulin G determine the site-specific glycosylation profiles and modulate the dynamic motion of the Fc oligosaccharides

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7 January 2021

Mapping and comparison of the interaction sites on the Fc region of IgG responsible for triggering antibody dependent cellular cytotoxicity (ADCC) through different types of human Fc gamma receptor

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High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

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7 January 2021

Expression and characterization of truncated forms of humanized L243 IgG1. Architectural features can influence synthesis of its oligosaccharide chains and affect superoxide production triggered through human Fcgamma receptor I

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7 January 2021

Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution

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7 January 2021

Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa

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7 January 2021

The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex

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The structure of a human type III Fcgamma receptor in complex with Fc

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Clinical relevance of Fc gamma receptor polymorphisms

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7 January 2021

Structural basis of the interaction between IgG and fcγ receptors

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7 January 2021

A conformational change in the Fc precludes the binding of two Fcgamma receptor molecules to one IgG.

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7 January 2021

Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha

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7 January 2021

Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding

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7 January 2021

The Human Low Affinity Fcγ Receptors IIa, IIb, and III Bind IgG with Fast Kinetics and Distinct Thermodynamic Properties

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7 January 2021

Recognition of IgG by Fcgamma receptor. The role of Fc glycosylation and the binding of peptide inhibitors

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7 January 2021

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene

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7 January 2021

IgA and the IgA Fc receptor.

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Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89

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7 January 2021

Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets

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7 January 2021

Inflammation in autoimmunity: receptors for IgG revisited

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7 January 2021

Fc receptors and immunity to parasites

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7 January 2021

10.1016/S0165-2478(02)00019-6

Identifiers

DOI

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3 August 2017

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