(Q34517140)

2 August 2017

title

The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase (English)

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2 August 2017

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B H Kwok

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2 August 2017

B Koh

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2 August 2017

M I Ndubuisi

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2 August 2017

M Elofsson

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2 August 2017

C M Crews

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2 August 2017

publication date

1 August 2001

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2 August 2017

published in

Chemistry and Biology

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

759-766

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

2 August 2017

cites work

1 reference

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7 January 2021

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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7 January 2021

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

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7 January 2021

Catalysis by a multiprotein IkappaB kinase complex

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https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

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7 January 2021

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

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7 January 2021

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

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7 January 2021

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

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7 January 2021

IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex

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7 January 2021

NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

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7 January 2021

NAK is an IkappaB kinase-activating kinase

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7 January 2021

Safety issues with herbal medicine

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7 January 2021

Nahua indian medicinal plants (Mexico): Inhibitory activity on NF-κB as an anti-inflammatory model and antibacterial effects

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7 January 2021

Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB.

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7 January 2021

Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta

1 reference

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7 January 2021

Study of three sesquiterpene lactones from Tithonia diversifolia on their anti-inflammatory activity using the transcription factor NF-kappa B and enzymes of the arachidonic acid pathway as targets

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65

1 reference

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7 January 2021

Inhibition of transcription factor NF-kappaB by sesquiterpene lactones: a proposed molecular mechanism of action

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7 January 2021

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

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https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

Identification and characterization of an IkappaB kinase

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https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

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7 January 2021

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

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7 January 2021

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase

1 reference

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7 January 2021

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

Anti-inflammatory activity of sesquiterpene lactones and related compounds

1 reference

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7 January 2021

Anti-inflammatory effects of South American Tanacetum vulgare

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7 January 2021

JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

The IKK complex: an integrator of all signals that activate NF-kappaB?

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

Sulindac inhibits activation of the NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

Active and inactive protein kinases: structural basis for regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

CIKS, a connection to Ikappa B kinase and stress-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

Act1, an NF-kappa B-activating protein

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2801%2900049-7

7 January 2021

10.1016/S1074-5521(01)00049-7

Identifiers

DOI

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2 August 2017

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