(Q34490497)

2 August 2017

title

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA (English)

1 reference

identical protein binding

2 August 2017

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Gorka Lasso

1 reference

2 August 2017

Mikel Valle

1 reference

2 August 2017

Alan R Fersht

1 reference

2 August 2017

Andreas C Joerger

1 reference

2 August 2017

Roberto Melero

0 references

David Gil

0 references

Dmitry B Veprintsev

0 references

Sjors H W Scheres

1 reference

2 August 2017

author name string

Sridharan Rajagopalan

1 reference

2 August 2017

Melisa Lázaro

1 reference

2 August 2017

Tobias Brandt

1 reference

2 August 2017

José María Carazo

1 reference

2 August 2017

language of work or name

English

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publication date

22 December 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

1 reference

2 August 2017

volume

108

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2 August 2017

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2 August 2017

page(s)

557-562

1 reference

Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs

2 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Averaging of electron subtomograms and random conical tilt reconstructions through likelihood optimization.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Blinded by the Light: The Growing Complexity of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Crystal structure of a p53 core tetramer bound to DNA

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Tumor suppressor p53 slides on DNA with low friction and high stability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

GraFix: sample preparation for single-particle electron cryomicroscopy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

UCSF Chimera--a visualization system for exploratory research and analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

p53 contains large unstructured regions in its native state

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Structure of BamHI bound to nonspecific DNA: a model for DNA sliding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

EMAN: semiautomated software for high-resolution single-particle reconstructions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Covalent and noncovalent modifiers of the p53 protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

How p53 binds DNA as a tetramer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

p53, the cellular gatekeeper for growth and division

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Crystal structure of lac repressor core tetramer and its implications for DNA looping

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Solution structure of the tetrameric minimum transforming domain of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Regulation of the specific DNA binding function of p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Definition of a consensus binding site for p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Small peptides activate the latent sequence-specific DNA binding function of p53.

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015520107

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015520107

p53 linear diffusion along DNA requires its C terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015520107

Structural basis of DNA recognition by p53 tetramers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015520107

Regulation of DNA binding of p53 by its C-terminal domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015520107

Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015520107

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015520107

Angular reconstitution: a posteriori assignment of projection directions for 3D reconstruction.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021029

Interhelical angles in the solution structure of the oligomerization domain of p53: correction

27 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015520107

The C-terminus of p53: the more you learn the less you know

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21178074

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Facilitated search for specific genomic targets by p53 C-terminal basic DNA binding domain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21178074

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1015520107

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference