(Q34382976)

1 August 2017

title

RNA catalyses nuclear pre-mRNA splicing (English)

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1 August 2017

Sebastian M Fica

1 reference

1 August 2017

Nicole Tuttle

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1 August 2017

Thaddeus Novak

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1 August 2017

Nan-Sheng Li

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1 August 2017

Jun Lu

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1 August 2017

Prakash Koodathingal

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1 August 2017

Qing Dai

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1 August 2017

Jonathan P Staley

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1 August 2017

Joseph A Piccirilli

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1 August 2017

language of work or name

English

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publication date

6 November 2013

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1 August 2017

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inferred from page(s)

published in

Nature

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1 August 2017

volume

503

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1 August 2017

issue

7475

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1 August 2017

page(s)

229-234

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describes a project that uses

1 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4666680/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation

6 July 2018

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Crystal structure of Prp8 reveals active site cavity of the spliceosome

6 July 2018

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Visualizing Group II Intron Catalysis through the Stages of Splicing

6 July 2018

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Staying on message: ensuring fidelity in pre-mRNA splicing

6 July 2018

1 reference

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Structure of the yeast U2/U6 snRNA complex

6 July 2018

1 reference

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Splicing of an intervening sequence by protein-free human snRNAs

6 July 2018

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The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing

6 July 2018

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Expansion of the eukaryotic proteome by alternative splicing

6 July 2018

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Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components

6 July 2018

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Cwc25 is a novel splicing factor required after Prp2 and Yju2 to facilitate the first catalytic reaction

6 July 2018

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Identification of catalytic metal ion ligands in ribozymes

6 July 2018

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Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps

6 July 2018

1 reference

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The spliceosome: design principles of a dynamic RNP machine

6 July 2018

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A critical assessment of the utility of protein-free splicing systems

6 July 2018

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The use of simple model systems to study spliceosomal catalysis

6 July 2018

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Functional identification of ligands for a catalytic metal ion in group I introns

6 July 2018

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Crystal Structure of a Self-Spliced Group II Intron

6 July 2018

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The ribosomal peptidyl transferase

6 July 2018

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HB tag modules for PCR-based gene tagging and tandem affinity purification in Saccharomyces cerevisiae

6 July 2018

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Exon ligation is proofread by the DExD/H-box ATPase Prp22p

6 July 2018

1 reference

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Introns and the origin of nucleus-cytosol compartmentalization

6 July 2018

1 reference

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Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site

6 July 2018

1 reference

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Multiple functions for the invariant AGC triad of U6 snRNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

The Prp19p-associated complex in spliceosome activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

The antiquity of RNA-based evolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

A universal method to produce in vitro transcripts with homogeneous 3' ends

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

A catalytically active group II intron domain 5 can function in the U12-dependent spliceosome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Metal ion coordination by the AGC triad in domain 5 contributes to group II intron catalysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

The structural basis of ribosome activity in peptide bond synthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Three metal ions at the active site of the Tetrahymena group I ribozyme

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Defining functional groups, core structural features and inter-domain tertiary contacts essential for group II intron self-splicing: a NAIM analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

A general two-metal-ion mechanism for catalytic RNA

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

U6 snRNA function in nuclear pre-mRNA splicing: a phosphorothioate interference analysis of the U6 phosphate backbone.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Stability constants of magnesium and cadmium complexes of adenine nucleotides and thionucleotides and rate constants for formation and dissociation of magnesium-ATP and magnesium-ADP

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

In vitro assembly of yeast U6 snRNP: a functional assay

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

The chemistry of self-splicing RNA and RNA enzymes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

The generality of self-splicing RNA: relationship to nuclear mRNA splicing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

On the origin of RNA splicing and introns

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Two domains of yeast U6 small nuclear RNA required for both steps of nuclear precursor messenger RNA splicing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicingin vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

RNAtomy of the Spliceosome's heart

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Assembly and glycerol gradient isolation of yeast spliceosomes containing transcribed or synthetic U6 snRNA.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

A novel role for a U5 snRNP protein in 3' splice site selection.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Metal ion catalysis during splicing of premessenger RNA

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4666680

Separation of RNA Phosphorothioate Oligonucleotides by HPLC

9 December 2018

1 reference

12 December 2020

1 reference

12 December 2020

Catalytic site components common to both splicing steps of a group II intron

1 reference

12 December 2020

A new metal ion interaction in the Tetrahymena ribozyme reaction revealed by double sulfur substitution

1 reference

12 December 2020

Mechanism of RNase T1: concerted triester-like phosphoryl transfer via a catalytic three-centered hydrogen bond

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE12734

1 reference

Dimensions Publication ID

1 August 2017

0 references

1 reference

1 August 2017

1 reference