(Q34278406)

1 August 2017

title

A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine (English)

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1 August 2017

2 references

ChEBI release 2020-05-28

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Thilo Winzer

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1 August 2017

Valeria Gazda

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1 August 2017

Zhesi He

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1 August 2017

Filip Kaminski

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1 August 2017

Marcelo Kern

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1 August 2017

Tony R Larson

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1 August 2017

Yi Li

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1 August 2017

Fergus Meade

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1 August 2017

Roxana Teodor

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1 August 2017

Fabián E Vaistij

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1 August 2017

Carol Walker

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1 August 2017

Tim A Bowser

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1 August 2017

Ian A Graham

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1 August 2017

language of work or name

English

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publication date

31 May 2012

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full work available at URL

1 August 2017

https://www.science.org/cms/asset/8a7977b8-6065-4314-a9e2-89efd7304b22/pap.pdf

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19 March 2024

https://api.unpaywall.org/v2/10.1126/science.1220757?email=unpaywall_01@example.com

published in

Science

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1 August 2017

volume

336

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1 August 2017

issue

6089

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1 August 2017

page(s)

1704-1708

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https://api.unpaywall.org/v2/10.1126/science.1220757?email=unpaywall_01@example.com

1 August 2017

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19 March 2024

access restriction status

open access

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based on heuristic

inferred from online access status

cites work

Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1220757

Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses

21 January 2018

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Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine

21 January 2018

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The anti-cancer activity of noscapine: a review.

21 January 2018

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Tubulin-interactive natural products as anticancer agents

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Alkaloid biosynthesis: metabolism and trafficking.

21 January 2018

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Acetyl coenzyme A:salutaridinol-7-O-acetyltransferase from papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis

21 January 2018

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Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum

21 January 2018

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Molecular characterization of the salutaridinol 7-O-acetyltransferase involved in morphine biosynthesis in opium poppy Papaver somniferum

21 January 2018

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CYP719B1 is salutaridine synthase, the C-C phenol-coupling enzyme of morphine biosynthesis in opium poppy

21 January 2018

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Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy.

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Formation of plant metabolic gene clusters within dynamic chromosomal regions.

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Plant cis-acting regulatory DNA elements (PLACE) database: 1999

21 January 2018

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Enhancement of alkaloid production in opium and California poppy by transactivation using heterologous regulatory factors

21 January 2018

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Identification of a WRKY protein as a transcriptional regulator of benzylisoquinoline alkaloid biosynthesis in Coptis japonica.

21 January 2018

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Virus-induced gene silencing is an effective tool for assaying gene function in the basal eudicot species Papaver somniferum (opium poppy).

21 January 2018

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Characterization of two methylenedioxy bridge-forming cytochrome P450-dependent enzymes of alkaloid formation in the Mexican prickly poppy Argemone mexicana

21 January 2018

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CYP719A subfamily of cytochrome P450 oxygenases and isoquinoline alkaloid biosynthesis in Eschscholzia californica

21 January 2018

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Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy

21 January 2018

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Genomic clustering of cyanogenic glucoside biosynthetic genes aids their identification inLotus japonicusand suggests the repeated evolution of this chemical defence pathway

21 January 2018

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Metabolic diversification--independent assembly of operon-like gene clusters in different plants.

21 January 2018

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Analysis of a chemical plant defense mechanism in grasses

21 January 2018

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CYP76M7 is an ent-cassadiene C11alpha-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice

21 January 2018

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From hormones to secondary metabolism: the emergence of metabolic gene clusters in plants

21 January 2018

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Parallel tagged sequencing on the 454 platform

21 January 2018

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CAP3: A DNA sequence assembly program

21 January 2018

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

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XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification

21 January 2018

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Highly sensitive feature detection for high resolution LC/MS

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1220757

CAMERA: an integrated strategy for compound spectra extraction and annotation of liquid chromatography/mass spectrometry data sets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1220757

One large-insert plant-transformation-competent BIBAC library and three BAC libraries of Japonica rice for genome research in rice and other grasses

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1220757

Ab initio gene finding in Drosophila genomic DNA

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.1220757

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1220757

Tobacco Rar1, EDS1 and NPR1/NIM1 like genes are required for N-mediated resistance to tobacco mosaic virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1220757

Technical Advance. Tobacco rattle virus as a vector for analysis of gene function by silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1220757

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1220757

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1220757

Biodiversity in the alkaloids of Turkish Papaver species

21 January 2018

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.1351/PAC200274040557

20 August 2023

Identifiers

DOI

10.1126/SCIENCE.1220757

1 reference

1 August 2017

1 reference