(Q34277732)

1 August 2017

title

Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice (English)

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1 August 2017

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Koji Aoki

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1 August 2017

Yoshitaka Tamai

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1 August 2017

Shigeo Horiike

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1 August 2017

Masanobu Oshima

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1 August 2017

Makoto M Taketo

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1 August 2017

language of work or name

English

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publication date

16 November 2003

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

323-330

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Expression of the caudal gene in the germ line of Drosophila: formation of an RNA and protein gradient during early embryogenesis

1 August 2017

cites work

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7 January 2021

Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes

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7 January 2021

Intestine-specific gene transcription

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7 January 2021

Key role of the Cdx2 homeobox gene in extracellular matrix-mediated intestinal cell differentiation

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7 January 2021

Homeosis and intestinal tumours in Cdx2 mutant mice

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7 January 2021

Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis

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7 January 2021

CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling

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7 January 2021

Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon

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7 January 2021

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

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7 January 2021

Intestinal adenomas can develop with a stable karyotype and stable microsatellites

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7 January 2021

A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.

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7 January 2021

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

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7 January 2021

Cancer predisposition caused by elevated mitotic recombination in Bloom mice

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7 January 2021

Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

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7 January 2021

Mutations in the APC tumour suppressor gene cause chromosomal instability

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7 January 2021

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

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7 January 2021

Defects in mismatch repair occur afterAPC mutations in the pathogenesis of sporadic colorectal tumours

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7 January 2021

Growth-factor-dependent mitogenesis requires two distinct phases of signalling

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7 January 2021

Ribosomal S6 kinase signaling and the control of translation

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7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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7 January 2021

Cyclin-dependent regulation of G1 in mammalian fibroblasts.

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7 January 2021

Deregulated cyclin E induces chromosome instability

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7 January 2021

Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium

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7 January 2021

When checkpoints fail

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7 January 2021

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

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7 January 2021

Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.

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7 January 2021

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

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7 January 2021

Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia

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7 January 2021

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.

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7 January 2021

Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability

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7 January 2021

Somatic recombination redux.

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7 January 2021

TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

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7 January 2021

TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

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7 January 2021

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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7 January 2021

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

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7 January 2021

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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7 January 2021

DLD-1 and HCT-15 cell lines derived separately from colorectal carcinomas have totally different chromosome changes but the same genetic origin

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7 January 2021

Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria

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7 January 2021

Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo

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7 January 2021

Identifiers

DOI

10.1038/NG1265

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1 August 2017

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