(Q34236816)

31 July 2017

title

Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth (English)

1 reference

31 July 2017

Morris F White

1 reference

31 July 2017

Sunmin Park

1 reference

31 July 2017

Xiaocheng Dong

1 reference

31 July 2017

Xueying Lin

1 reference

31 July 2017

Kyle Copps

series ordinal

1 reference

31 July 2017

Xianjin Yi

series ordinal

1 reference

31 July 2017

language of work or name

English

0 references

publication date

22 December 2005

1 reference

Journal of Clinical Investigation

31 July 2017

published in

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31 July 2017

volume

116

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31 July 2017

1 reference

31 July 2017

page(s)

101-114

1 reference

describes a project that uses

31 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1319221/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice

28 July 2018

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Hypothalamic K(ATP) channels control hepatic glucose production

28 July 2018

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28 July 2018

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Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

28 July 2018

1 reference

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28 July 2018

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28 July 2018

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Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

28 July 2018

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Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

28 July 2018

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28 July 2018

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Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element

28 July 2018

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28 July 2018

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28 July 2018

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Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

28 July 2018

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28 July 2018

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Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

28 July 2018

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Control of glycogen deposition.

28 July 2018

1 reference

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Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver.

28 July 2018

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Differing Roles of Akt and Serum- and Glucocorticoid-regulated Kinase in Glucose Metabolism, DNA Synthesis, and Oncogenic Activity

28 July 2018

1 reference

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Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.

28 July 2018

1 reference

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Insulin's effect on glucose production: direct or indirect?

28 July 2018

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Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice

28 July 2018

1 reference

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Regulation of the activity of the pyruvate dehydrogenase complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Pdx1 restores beta cell function in Irs2 knockout mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Insulin signalling and the regulation of glucose and lipid metabolism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

GSK3 takes centre stage more than 20 years after its discovery

28 July 2018

1 reference

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Evidence for a circulating islet cell growth factor in insulin-resistant states

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Disruption of IRS-2 causes type 2 diabetes in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Signaling through scaffold, anchoring, and adaptor proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

The IRS-signalling system during insulin and cytokine action

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Metabolism: a higher power for insulin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Type 2 diabetes-a matter of beta-cell life and death?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Diabetes: outfoxing insulin resistance?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

SREBPs suppress IRS-2-mediated insulin signalling in the liver

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Molecular insights into insulin action and secretion

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Insulin signaling after exercise in insulin receptor substrate-2-deficient mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

The functional significance of Shc in insulin signaling as a substrate of the insulin receptor

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

28 October 2018

1 reference

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

12 December 2020

IRS-2 pathways integrate female reproduction and energy homeostasis

1 reference

12 December 2020

Insulin signaling in health and disease

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI25735

1 reference

31 July 2017

1 reference

31 July 2017

1 reference