(Q34234252)

31 July 2017

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title

Interfering with disease: opportunities and roadblocks to harnessing RNA interference (English)

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31 July 2017

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Judy Lieberman

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31 July 2017

Erwei Song

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31 July 2017

Sang-Kyung Lee

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31 July 2017

Premlata Shankar

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31 July 2017

publication date

1 September 2003

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Trends in Molecular Medicine

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

397-403

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U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

31 July 2017

cites work

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12 December 2020

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

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12 December 2020

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

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12 December 2020

Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action

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12 December 2020

Modulation of HIV-1 replication by RNA interference

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12 December 2020

RNA interference is mediated by 21- and 22-nucleotide RNAs

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12 December 2020

Specific interference by ingested dsRNA

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12 December 2020

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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12 December 2020

Role for a bidentate ribonuclease in the initiation step of RNA interference

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12 December 2020

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

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12 December 2020

RNA interference: listening to the sound of silence

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12 December 2020

Targeted mRNA degradation by double-stranded RNA in vitro

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12 December 2020

Gene silencing using micro-RNA designed hairpins

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12 December 2020

Establishment and maintenance of a heterochromatin domain

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12 December 2020

Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

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12 December 2020

Small interfering RNA-mediated gene silencing in T lymphocytes

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12 December 2020

Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression

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12 December 2020

An ATF2-derived peptide sensitizes melanomas to apoptosis and inhibits their growth and metastasis

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12 December 2020

Short interfering RNA-directed inhibition of hepatitis B virus replication

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12 December 2020

siRNAs can function as miRNAs

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12 December 2020

Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo.

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12 December 2020

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

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12 December 2020

A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans

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12 December 2020

Argonaute2, a link between genetic and biochemical analyses of RNAi

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12 December 2020

RNA-directed de novo methylation of genomic sequences in plants.

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12 December 2020

Expression profiling reveals off-target gene regulation by RNAi

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12 December 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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12 December 2020

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

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12 December 2020

Stable suppression of tumorigenicity by virus-mediated RNA interference

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12 December 2020

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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12 December 2020

RNA interference targeting Fas protects mice from fulminant hepatitis

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12 December 2020

Regulation of the interferon-induced PKR: can viruses cope?

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12 December 2020

Induction and suppression of RNA silencing by an animal virus

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12 December 2020

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages

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12 December 2020

A biochemical framework for RNA silencing in plants

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12 December 2020

Fascination with 2-5A-Dependent RNase: A Unique Enzyme That Functions in Interferon Action*

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12 December 2020

RNA interference in adult mice.

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12 December 2020

Effective expression of small interfering RNA in human cells

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12 December 2020

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12 December 2020

ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation

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12 December 2020

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

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12 December 2020

Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference

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12 December 2020

Caspase 8 small interfering RNA prevents acute liver failure in mice

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12 December 2020

RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast

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12 December 2020

Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin

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12 December 2020

Short interfering RNA confers intracellular antiviral immunity in human cells

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12 December 2020

siRNA-directed inhibition of HIV-1 infection

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12 December 2020

RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription

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12 December 2020

Interferon-induced and double-stranded RNA-activated enzymes: a specific protein kinase and 2',5'-oligoadenylate synthetases

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12 December 2020

ATP requirements and small interfering RNA structure in the RNA interference pathway

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12 December 2020

The rde-1 gene, RNA interference, and transposon silencing in C. elegans

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12 December 2020

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

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12 December 2020

Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics

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12 December 2020

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

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12 December 2020

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12 December 2020

Tolerance for mutations and chemical modifications in a siRNA.

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12 December 2020

RNA interference--2001.

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12 December 2020

Nuclear targeting of macromolecular polyanions by an HIV-Tat derived peptide. Role for cell-surface proteoglycans.

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12 December 2020

Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos.

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12 December 2020

Inhibition of retroviral pathogenesis by RNA interference.

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12 December 2020

Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway.

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12 December 2020

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

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12 December 2020

Gene silencing in mammals by small interfering RNAs

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12 December 2020

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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12 December 2020

RNA interference is a functional pathway with therapeutic potential in human myeloid leukemia cell lines

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12 December 2020

On the role of RNA amplification in dsRNA-triggered gene silencing

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12 December 2020

The genetics of RNA silencing

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12 December 2020

Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells

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12 December 2020

Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference

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12 December 2020

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.

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12 December 2020

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

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12 December 2020

Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference

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12 December 2020

siRNA-mediated gene silencing in vitro and in vivo.

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12 December 2020

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

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12 December 2020

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

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12 December 2020

Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection

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12 December 2020

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

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12 December 2020

A species of small antisense RNA in posttranscriptional gene silencing in plants

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12 December 2020

Two classes of short interfering RNA in RNA silencing

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12 December 2020

Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference

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12 December 2020

Cosuppression of nonhomologous transgenes in Drosophila involves mutually related endogenous sequences.

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12 December 2020

Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs

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12 December 2020

Altered gene expression in plants due to trans interactions between homologous genes

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12 December 2020

Gene silencing by systemic delivery of synthetic siRNAs in adult mice

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12 December 2020

Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

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12 December 2020

Lentivirus-delivered stable gene silencing by RNAi in primary cells

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12 December 2020

Inhibition of hepatitis B virus in mice by RNA interference

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12 December 2020

Isolation of an RNA-directed RNA polymerase-specific cDNA clone from tomato

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12 December 2020

Genetic analysis of interferon and other mammalian signaling pathways.

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12 December 2020

Chalcone synthase cosuppression phenotypes in petunia flowers: comparison of sense vs. antisense constructs and single-copy vs. complex T-DNA sequences

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12 December 2020

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

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12 December 2020

Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi).

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12 December 2020

A microRNA in a multiple-turnover RNAi enzyme complex

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12 December 2020

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

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12 December 2020

10.1016/S1471-4914(03)00143-6

Identifiers

DOI

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31 July 2017

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