(Q34150579)

31 July 2017

title

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization (English)

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31 July 2017

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Jose Baselga

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31 July 2017

Carlos L Arteaga

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31 July 2017

Incheol Shin

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31 July 2017

F Michael Yakes

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31 July 2017

Federico Rojo

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31 July 2017

Nah-Young Shin

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31 July 2017

Andrei V Bakin

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31 July 2017

language of work or name

English

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publication date

16 September 2002

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31 July 2017

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

1145-1152

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CDK inhibitors: positive and negative regulators of G1-phase progression

31 July 2017

cites work

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7 January 2021

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

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7 January 2021

p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

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7 January 2021

Translational control of p27Kip1 accumulation during the cell cycle

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7 January 2021

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

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7 January 2021

ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

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7 January 2021

Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

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7 January 2021

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

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7 January 2021

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

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7 January 2021

Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes

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7 January 2021

Cyclin E-CDK2 is a regulator of p27Kip1.

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7 January 2021

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

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7 January 2021

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

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7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

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7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

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7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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7 January 2021

Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F

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7 January 2021

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

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7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

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7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

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7 January 2021

Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Clambda do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription

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7 January 2021

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

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7 January 2021

Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells

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7 January 2021

Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells

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7 January 2021

Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

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7 January 2021

Carboxyl-terminal domain of p27Kip1 activates CDC2.

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7 January 2021

Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation.

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7 January 2021

Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway

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7 January 2021

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

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7 January 2021

Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9.

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7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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7 January 2021

Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation.

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7 January 2021

p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases

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7 January 2021

Phosphopeptide mapping and phosphoamino acid analysis by electrophoresis and chromatography on thin-layer cellulose plates

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7 January 2021

Identifiers

DOI

10.1038/NM759

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Dimensions Publication ID

31 July 2017

1007149132

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