(Q34148542)

31 July 2017

title

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. (English)

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31 July 2017

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Domenico Accili

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31 July 2017

Jun Nakae

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31 July 2017

William H Biggs

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31 July 2017

Tadahiro Kitamura

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31 July 2017

Webster K Cavenee

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31 July 2017

Christopher V E Wright

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31 July 2017

Karen C Arden

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31 July 2017

language of work or name

English

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publication date

3 September 2002

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31 July 2017

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

245-253

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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

31 July 2017

cites work

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Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM?

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Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.

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7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

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7 January 2021

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

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7 January 2021

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

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7 January 2021

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

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7 January 2021

Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice

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7 January 2021

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

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7 January 2021

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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7 January 2021

Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span

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7 January 2021

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

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7 January 2021

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

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7 January 2021

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway

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7 January 2021

Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily

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7 January 2021

DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells

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7 January 2021

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

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7 January 2021

Genetic modifiers of the insulin resistance phenotype in mice.

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7 January 2021

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

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7 January 2021

Foxa3 (hepatocyte nuclear factor 3gamma ) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

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7 January 2021

The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas

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7 January 2021

Transthyretin immunoreactivity in human and porcine liver, choroid plexus, and pancreatic islets

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7 January 2021

Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo

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7 January 2021

In vitro cultivation of human islets from expanded ductal tissue

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7 January 2021

Extra-insular beta cells associated with ductules are frequent in adult human pancreas

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7 January 2021

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration

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7 January 2021

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

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7 January 2021

Insights into insulin resistance and type 2 diabetes from knockout mouse models

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7 January 2021

Life and death of the pancreatic beta cells

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7 January 2021

Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor

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7 January 2021

Identifiers

DOI

10.1038/NG890

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31 July 2017

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