(Q34137733)

31 July 2017

title

CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery (English)

1 reference

31 July 2017

main subject

lymphocyte activation

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20837541

12 July 2024

Maxim N Artyomov

1 reference

31 July 2017

Mark M. Davis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20837541

12 July 2024

Mieszko Lis

1 reference

31 July 2017

Srinivas Devadas

series ordinal

1 reference

31 July 2017

Arup K. Chakraborty

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20837541

12 July 2024

language of work or name

English

0 references

publication date

13 September 2010

1 reference

full work available at URL

31 July 2017

https://europepmc.org/articles/pmc2947881?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20837541

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20837541/?tool=EBI

12 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20837541

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20837541/pdf/?tool=EBI

12 July 2024

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20837541

https://europepmc.org/articles/PMC2947881

12 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20837541

https://europepmc.org/articles/PMC2947881?pdf=render

12 July 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20837541

https://doi.org/10.1073/pnas.1010568107

12 July 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20837541

https://pnas.org/doi/pdf/10.1073/pnas.1010568107

12 July 2024

1 reference

DOI

10.1073/PNAS.1010568107

https://api.crossref.org/works/10.1073/PNAS.1010568107

Proceedings of the National Academy of Sciences of the United States of America

12 July 2024

published in

1 reference

31 July 2017

volume

107

1 reference

31 July 2017

1 reference

31 July 2017

page(s)

16916-16921

1 reference

Efficient stochastic simulation of reaction-diffusion processes via direct compilation

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Rule-based modeling of biochemical systems with BioNetGen

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Digital signaling and hysteresis characterize ras activation in lymphoid cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Stochastic reaction-diffusion simulation with MesoRD.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

CD4-independent T cells impair TCR triggering of CD4-dependent T cells: a putative mechanism for T cell affinity maturation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

The immunological synapse: a molecular machine controlling T cell activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

A therapeutic CD4 monoclonal antibody inhibits TCR-zeta chain phosphorylation, zeta-associated protein of 70-kDa Tyr319 phosphorylation, and TCR internalization in primary human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Altered proximal T-cell receptor signalling events in mouse CD4+ T cells in the presence of anti-CD4 monoclonal antibodies: evidence for reduced phosphorylation of Zap-70 and LAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Exact stochastic simulation of coupled chemical reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1010568107

Redox equilibrium in mucosal T cells tunes the intestinal TCR signaling threshold

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2947881

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20837541

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20837541

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1010568107

1 reference

31 July 2017

0 references

1 reference

31 July 2017

1 reference