(Q34095979)

31 July 2017

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title

Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases (English)

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31 July 2017

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Yihai Cao

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31 July 2017

language of work or name

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1 February 2010

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Nature Reviews Drug Discovery

31 July 2017

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

107-115

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Angiogenesis modulates adipogenesis and obesity

31 July 2017

cites work

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The obesity pipeline: current strategies in the development of anti-obesity drugs

31 March 2020

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Angiogenesis in cancer, vascular, rheumatoid and other disease

31 March 2020

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31 March 2020

Angiogenesis and obesity

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Endogenous angiogenesis inhibitors and their therapeutic implications

31 March 2020

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Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis

31 March 2020

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

31 March 2020

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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

31 March 2020

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Endogenous inhibitors of angiogenesis.

31 March 2020

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Sorafenib in advanced clear-cell renal-cell carcinoma

31 March 2020

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Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

31 March 2020

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31 March 2020

1 reference

Sunitinib versus interferon alfa in metastatic renal-cell carcinoma

31 March 2020

1 reference

Pegaptanib for neovascular age-related macular degeneration

31 March 2020

1 reference

The price of sight--ranibizumab, bevacizumab, and the treatment of macular degeneration

31 March 2020

1 reference

Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox

31 March 2020

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Retinal angiogenesis in development and disease

31 March 2020

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UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality

31 March 2020

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Why we should put clothes on mice

31 March 2020

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Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

31 March 2020

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Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells

31 March 2020

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White fat progenitor cells reside in the adipose vasculature.

31 March 2020

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Inflammation and metabolic disorders

31 March 2020

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Obesity: the two faces of fat

31 March 2020

1 reference

Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF.

31 March 2020

1 reference

VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature

31 March 2020

1 reference

Leptin and the regulation of body weight in mammals

31 March 2020

1 reference

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

31 March 2020

1 reference

Endothelial dysfunction in insulin resistance and type 2 diabetes

31 March 2020

1 reference

Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

31 March 2020

1 reference

Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications

31 March 2020

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Mechanisms of obesity and related pathologies: the macro- and microcirculation of adipose tissue

31 March 2020

1 reference

Biological action of leptin as an angiogenic factor

31 March 2020

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Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells.

31 March 2020

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1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes

31 March 2020

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Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis.

31 March 2020

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Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells

31 March 2020

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Effect of plasminogen activator inhibitor-1 on adipogenesis in vivo.

31 March 2020

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Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.

31 March 2020

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Modulation of angiogenesis during adipose tissue development in murine models of obesity

31 March 2020

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Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo

31 March 2020

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Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells

31 March 2020

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Thrombospondins and tumor angiogenesis

31 March 2020

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Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

31 March 2020

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Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?

31 March 2020

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The multifaceted circulating endothelial cell in cancer: towards marker and target identification.

31 March 2020

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Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

31 March 2020

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Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors.

31 March 2020

1 reference

Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization

31 March 2020

1 reference

Mesenchymal stem cells and their potential as cardiac therapeutics

31 March 2020

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Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis

31 March 2020

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31 March 2020

Adipose-derived cells

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Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction

31 March 2020

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Resident endothelial precursors in muscle, adipose, and dermis contribute to postnatal vasculogenesis

31 March 2020

1 reference

Medicine. Can we nip obesity in its vascular bud?

31 March 2020

1 reference

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

31 March 2020

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Function of GATA transcription factors in preadipocyte-adipocyte transition

31 March 2020

1 reference

PRDM16 controls a brown fat/skeletal muscle switch

31 March 2020

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Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice

31 March 2020

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Adipose tissue mass can be regulated through the vasculature

31 March 2020

1 reference

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

31 March 2020

1 reference

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

31 March 2020

1 reference

Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells

31 March 2020

1 reference

Paracrine Regulation of Angiogenesis and Adipocyte Differentiation During In Vivo Adipogenesis

31 March 2020

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Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732.

31 March 2020

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Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470.

31 March 2020

1 reference

Molecular mechanisms and therapeutic development of angiogenesis inhibitors

31 March 2020

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Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistance.

31 March 2020

1 reference

Reversal of obesity by targeted ablation of adipose tissue

31 March 2020

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Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis

31 March 2020

1 reference

Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production

31 March 2020

1 reference

Effect of matrix metalloproteinase inhibition on adipose tissue development

31 March 2020

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Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation

31 March 2020

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Matrix metalloproteinase inhibition impairs adipose tissue development in mice

31 March 2020

1 reference

On the role of placental growth factor in murine adipogenesis

31 March 2020

1 reference

Impaired adipose tissue development in mice with inactivation of placental growth factor function

31 March 2020

1 reference

Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice

31 March 2020

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Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes.

31 March 2020

1 reference

Can EGCG reduce abdominal fat in obese subjects?

31 March 2020

1 reference

Tea, obesity, and diabetes

31 March 2020

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Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes

31 March 2020

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Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation

31 March 2020

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Angiogenesis inhibited by drinking tea.

31 March 2020

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Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

31 March 2020

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Fat hormones pull their weight in the CNS.

31 March 2020

1 reference

31 March 2020

You are what you secrete

1 reference

31 March 2020

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Obesity in the new millennium

31 March 2020

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Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

31 March 2020

1 reference

Human leptin levels are pulsatile and inversely related to pituitary-adrenal function.

31 March 2020

1 reference

Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer

31 March 2020

1 reference

Assessment and management of foot disease in patients with diabetes

31 March 2020

1 reference

Measurement of phosphorylated extracellular signal-regulated kinase 1 and 2 in an undergraduate teaching laboratory with ALPHAscreen technology.

31 March 2020

1 reference

Angiogenesis in life, disease and medicine

31 March 2020

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Angiogenesis as a therapeutic target

31 March 2020

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Common mechanisms of nerve and blood vessel wiring

31 March 2020

1 reference

VEGF gene therapy: stimulating angiogenesis or angioma-genesis?

31 March 2020

1 reference

Vascular endothelial growth factor enhances atherosclerotic plaque progression

31 March 2020

1 reference

Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma

31 March 2020

1 reference

Too many vessels? Not enough? The wrong kind? The VEGF debate continues

31 March 2020

1 reference

Obesity as a medical problem

31 March 2020

1 reference

Medicine. Bypassing medicine to treat diabetes

31 March 2020

1 reference

Emerging drugs for non-small cell lung cancer

31 March 2020

1 reference

Obesity and prostate cancer: a role for adipokines

31 March 2020

1 reference

Pegaptanib and age-related macular degeneration

31 March 2020

1 reference

Ranibizumab versus verteporfin for neovascular age-related macular degeneration.

31 March 2020

1 reference

Ranibizumab for neovascular age-related macular degeneration

31 March 2020

1 reference

Clinical protocol: Phase I trial to evaluate the safety of H5.020CMV.PDGF-B for the treatment of a diabetic insensate foot ulcer

31 March 2020

1 reference

Eye disorders in diabetes: potential drug targets

31 March 2020

1 reference

Ranibizumab for diabetic retinopathy

31 March 2020

1 reference

Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy

31 March 2020

1 reference

31 March 2020

1 reference

Becaplermin gel (PDGF-BB) as topical wound therapy. Plastic Surgery Educational Foundation DATA Committee

31 March 2020

1 reference

Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers

31 March 2020

1 reference

How obesity causes diabetes: not a tall tale

31 March 2020

1 reference

The many faces of PPARgamma

31 March 2020

1 reference

Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice

31 March 2020

1 reference

PPARalpha deficiency in inflammatory cells suppresses tumor growth

31 March 2020

1 reference

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

31 March 2020

1 reference

Angiogenic growth factor synergism in a murine tissue engineering model of angiogenesis and adipogenesis

31 March 2020

1 reference

Human adipose tissue-derived mesenchymal stem cells improve postnatal neovascularization in a mouse model of hindlimb ischemia

31 March 2020

1 reference

Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy

31 March 2020

1 reference

Fat tissue: an underappreciated source of stem cells for biotechnology

31 March 2020

1 reference

Vascular fate of adipose tissue-derived adult stromal cells in the ischemic murine brain: A combined imaging-histological study.

31 March 2020

1 reference

Effects of surface-modified scaffolds on the growth and differentiation of mouse adipose-derived stromal cells.

31 March 2020

1 reference

Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis.

31 March 2020

1 reference

Fate of amnion-derived stem cells transplanted to the fetal rat brain: migration, survival and differentiation

31 March 2020

1 reference

Functional implications of CD34 expression in human adipose-derived stem/progenitor cells.

31 March 2020

1 reference

A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks

31 March 2020

1 reference

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

31 March 2020

1 reference

A new twist on brown fat metabolism.

31 March 2020

1 reference

Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome

31 March 2020

1 reference

Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system

31 March 2020

1 reference

12 December 2020

Leptin in the regulation of immunity, inflammation, and hematopoiesis

1 reference

12 December 2020

Positive and negative modulation of angiogenesis by VEGFR1 ligands

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12 December 2020

Angiogenic role of LYVE-1-positive macrophages in adipose tissue.

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12 December 2020

Identifiers

DOI

10.1038/NRD3055

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Dimensions Publication ID

31 July 2017

1035467577

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