(Q34030951)

English

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

scientific article

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Christian Haass

10

object named as

Christian Haass

0 references

4

object named as

Dieter Edbauer

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

6

object named as

Anja Capell

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Bernardino F. Ghetti

9

object named as

Bernardino Ghetti

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

5

object named as

Jill Murrell

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

author name string

Tobias Moehlmann

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Edith Winkler

2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Xuefeng Xia

3

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Christoph Kaether

7

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Hui Zheng

8

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Harald Steiner

11

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

language of work or name

0 references

publication date

4 June 2002

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

99

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

8025-8030

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Intramembrane proteolysis by presenilins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Notch signaling: from the outside in

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Evidence that Abeta42 plasma levels in presenilin-1 mutation carriers do not allow for prediction of their clinical phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Translating cell biology into therapeutic advances in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Microtubule-dependent transport of secretory vesicles visualized in real time with a GFP-tagged secretory protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123014

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

A novel presenilin 1 mutation (Leu166Arg) associated with early-onset Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.112686799

21 January 2018

Cell-free assays for gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12048239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/12048239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12048239

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.112686799

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

2002PNAS...99.8025M

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34030951&oldid=1786787321"