(Q33950703)

30 July 2017

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title

Trk receptors: mediators of neurotrophin action (English)

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30 July 2017

Patapoutian A

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30 July 2017

Reichardt LF

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30 July 2017

publication date

1 June 2001

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Current Opinion in Neurobiology

30 July 2017

language of work

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

272-280

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Neurotrophin signal transduction in the nervous system

30 July 2017

cites work

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7 January 2021

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7 January 2021

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7 January 2021

Nerve growth factor signaling, neuroprotection, and neural repair

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7 January 2021

Evolution of the vertebrate neurotrophin and Trk receptor gene families

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7 January 2021

Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR

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7 January 2021

Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons

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7 January 2021

High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors

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7 January 2021

Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC

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7 January 2021

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

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7 January 2021

TrkA Tyrosine Residues Involved in NGF‐induced Neurite Outgrowth of PC12 Cells

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7 January 2021

Identification and characterization of novel substrates of Trk receptors in developing neurons

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7 January 2021

A TrkA-selective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signals

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7 January 2021

Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.

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7 January 2021

Extracellular-signal-regulated kinase signalling in neurons

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7 January 2021

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

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7 January 2021

Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation

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7 January 2021

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

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7 January 2021

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

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7 January 2021

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

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7 January 2021

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

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7 January 2021

CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.

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7 January 2021

A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation

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7 January 2021

EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival

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https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

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7 January 2021

Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons

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7 January 2021

Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

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7 January 2021

Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Apoptosis in the nervous system

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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7 January 2021

Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro

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7 January 2021

Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons.

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7 January 2021

Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

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7 January 2021

Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells

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7 January 2021

Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation

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7 January 2021

Protein traffic in the yeast endocytic and vacuolar protein sorting pathways

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7 January 2021

Spatially and Functionally Distinct Roles of the PI3-K Effector Pathway during NGF Signaling in Sympathetic Neurons

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7 January 2021

Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses.

1 reference

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7 January 2021

Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA

1 reference

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7 January 2021

From membrane to cytoskeleton: enabling a connection

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7 January 2021

Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor

1 reference

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7 January 2021

A novel juxtamembrane deletion in rat TrkA blocks differentiative but not mitogenic cell signaling in response to nerve growth factor.

1 reference

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7 January 2021

Signaling to Rho GTPases

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7 January 2021

Rho GTPases and their effector proteins

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7 January 2021

Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Ras regulates sympathetic neuron survival by suppressing the p53-mediated cell death pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Brain-derived neurotrophic factor binding to the p75 neurotrophin receptor reduces TrkA signaling while increasing serine phosphorylation in the TrkA intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Specific Subtypes of Cutaneous Mechanoreceptors Require Neurotrophin-3 Following Peripheral Target Innervation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

A role for BDNF in mechanosensation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Signal transduction underlying growth cone guidance by diffusible factors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Gating of BDNF-induced synaptic potentiation by cAMP.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Overexpression of nerve growth factor in epidermis disrupts the distribution and properties of sympathetic innervation in footpads.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Cell fate determination in the peripheral nervous system: the sympathoadrenal progenitor

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Neurotrophins, nociceptors, and pain

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Development of sensory neurons in the absence of NGF/TrkA signaling in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Widespread elimination of naturally occurring neuronal death in Bax-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Overexpression of nerve growth factor in skin selectively affects the survival and functional properties of nociceptors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Isolectin B(4)-positive and -negative nociceptors are functionally distinct.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Neurotrophins and hyperalgesia.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin

1 reference

https://api.crossref.org/works/10.1016%2FS0959-4388%2800%2900208-7

7 January 2021

10.1016/S0959-4388(00)00208-7

Identifiers

DOI

1 reference

30 July 2017

1 reference