(Q33764672)

29 July 2017

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title

Diverse and dynamic functions of the Sir silencing complex (English)

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29 July 2017

Guarente L

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29 July 2017

language of work or name

English

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publication date

1 November 1999

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29 July 2017

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

281-285

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Organization of the human genome

29 July 2017

cites work

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7 January 2021

Centromeres take flight: alpha satellite and the quest for the human centromere

1 reference

7 January 2021

Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila.

1 reference

7 January 2021

Yeast heterochromatin: regulation of its assembly and inheritance by histones

1 reference

7 January 2021

Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3.

1 reference

7 January 2021

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast

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7 January 2021

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation

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7 January 2021

Silencers and domains of generalized repression

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7 January 2021

DNA in transcriptionally silent chromatin assumes a distinct topology that is sensitive to cell cycle progression

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7 January 2021

Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription

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7 January 2021

Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.

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7 January 2021

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres

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7 January 2021

DNA end-joining: from yeast to man

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7 January 2021

Yeast Ku as a regulator of chromosomal DNA end structure

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7 January 2021

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres

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7 January 2021

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

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7 January 2021

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast

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7 January 2021

An unusual form of transcriptional silencing in yeast ribosomal DNA

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7 January 2021

Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA.

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7 January 2021

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

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7 January 2021

Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae

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7 January 2021

Yeast cell-type regulation of DNA repair

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7 January 2021

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

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7 January 2021

Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths.

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7 January 2021

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast

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7 January 2021

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

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7 January 2021

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

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7 January 2021

Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein

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7 January 2021

Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity

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7 January 2021

Yeast Hct1 is a regulator of Clb2 cyclin proteolysis

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7 January 2021

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

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7 January 2021

Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus

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7 January 2021

Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex

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7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

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7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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7 January 2021

Pch2 links chromatin silencing to meiotic checkpoint control.

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7 January 2021

ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis

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7 January 2021

Life span of individual yeast cells

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7 January 2021

Molecular mechanisms of yeast aging

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7 January 2021

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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7 January 2021

Extrachromosomal rDNA circles--a cause of aging in yeast

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7 January 2021

Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae

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7 January 2021

Elimination of replication block protein Fob1 extends the life span of yeast mother cells.

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7 January 2021

The shuffling of a mortal coil.

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7 January 2021

A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities

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7 January 2021

A replication fork barrier at the 3' end of yeast ribosomal RNA genes

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7 January 2021

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

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7 January 2021

Genome sequence of the nematode C. elegans: a platform for investigating biology

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7 January 2021

The conserved core of a human SIR2 homologue functions in yeast silencing

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7 January 2021

Phenotypic switching in Candida albicans is controlled by a SIR2 gene

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7 January 2021

cobB function is required for catabolism of propionate in Salmonella typhimurium LT2: evidence for existence of a substitute function for CobB within the 1,2-propanediol utilization (pdu) operon

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7 January 2021

Identifiers

DOI

10.1038/15458

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Dimensions Publication ID

29 July 2017

1042498922

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