(Q33292150)

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Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4.

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Europe PubMed Central

PubMed publication ID

25 July 2017

Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4. (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

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author name string

Menachem Katz

1

1 reference

Europe PubMed Central

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25 July 2017

Keren Shtiegman

2

1 reference

Europe PubMed Central

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25 July 2017

Pazit Tal-Or

3

1 reference

Europe PubMed Central

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25 July 2017

Liat Yakir

4

1 reference

Europe PubMed Central

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25 July 2017

Yaron Mosesson

5

1 reference

Europe PubMed Central

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25 July 2017

Daniel Harari

6

1 reference

Europe PubMed Central

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25 July 2017

Yossi Machluf

7

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Hironobu Asao

8

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Thomas Jovin

9

1 reference

Europe PubMed Central

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25 July 2017

Kazuo Sugamura

10

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Europe PubMed Central

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25 July 2017

Yosef Yarden

11

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Europe PubMed Central

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25 July 2017

publication date

1 October 2002

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Europe PubMed Central

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25 July 2017

1 reference

Europe PubMed Central

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25 July 2017

3

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Europe PubMed Central

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25 July 2017

10

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Europe PubMed Central

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25 July 2017

740-751

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases

1 reference

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Regulation of receptor tyrosine kinase signaling by endocytic trafficking

1 reference

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Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis

1 reference

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7 January 2021

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Protein regulation by monoubiquitin

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

1 reference

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7 January 2021

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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1 reference

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The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor

1 reference

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Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

1 reference

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A Di-leucine Signal in the Ubiquitin Moiety

1 reference

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A leucine-based determinant in the epidermal growth factor receptor juxtamembrane domain is required for the efficient transport of ligand-receptor complexes to lysosomes

1 reference

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7 January 2021

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Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

1 reference

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based on heuristic

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Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1 reference

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7 January 2021

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Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain

1 reference

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Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

1 reference

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7 January 2021

based on heuristic

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Epidermal growth factor induces ubiquitination of Eps15.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Hrs and hbp: possible regulators of endocytosis and exocytosis

1 reference

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7 January 2021

based on heuristic

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Hrs recruits clathrin to early endosomes

1 reference

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7 January 2021

based on heuristic

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FYVE fingers bind PtdIns(3)P

1 reference

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based on heuristic

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Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15

1 reference

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Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate

1 reference

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7 January 2021

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VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

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Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Early endosomal localization of hrs requires a sequence within the proline- and glutamine-rich region but not the FYVE finger

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

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Hrs, a Tyrosine Kinase Substrate with a Conserved Double Zinc Finger Domain, Is Localized to the Cytoplasmic Surface of Early Endosomes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

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Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

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A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

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Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

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Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains

1 reference

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based on heuristic

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Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth

1 reference

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7 January 2021

based on heuristic

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A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

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based on heuristic

inferred from DOI database lookup

Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation

1 reference

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based on heuristic

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Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

1 reference

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Comparison of fixation protocols for adherent cultured cells applied to a GFP fusion protein of the epidermal growth factor receptor

1 reference

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Movement of internalized ligand-receptor complexes along a continuous endosomal reticulum

1 reference

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based on heuristic

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Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1 reference

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A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems

1 reference

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Characterization of two polyubiquitin binding sites in the 26 S protease subunit 5a

1 reference

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based on heuristic

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Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

1 reference

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based on heuristic

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Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor.

1 reference

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7 January 2021

based on heuristic

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Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

inferred from DOI database lookup

A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

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Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-0854.2002.31006.X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1034/J.1600-0854.2002.31006.X

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 July 2017

ResearchGate publication ID

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