(Q32016682)

5 July 2017

title

Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases (English)

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5 July 2017

Landis DM

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5 July 2017

Loeb LA

series ordinal

1 reference

5 July 2017

language of work or name

English

0 references

publication date

1 October 1998

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Journal of Biological Chemistry

5 July 2017

published in

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5 July 2017

volume

273

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5 July 2017

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5 July 2017

page(s)

25809-25817

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STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLI

5 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Methotrexate-induced misincorporation of uracil into DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Atomic structure of thymidylate synthase: target for rational drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Structure-based discovery of inhibitors of thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Mechanism-based inhibition of thymidylate synthase by 5-(trifluoromethyl)-2'-deoxyuridine 5'-monophosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Escherichia coli thymidylate synthase: amino acid substitutions by suppression of amber nonsense mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

The catalytic mechanism and structure of thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Kinetics and thermodynamics of the interaction of 5-fluoro-2'-deoxyuridylate with thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

A rapid and efficient one-tube PCR-based mutagenesis technique using Pfu DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Tolerance of different proteins for amino acid diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Site-directed mutagenesis of mouse thymidylate synthase: alteration of Arg44 to Val44 in a conserved loop guarding the active site has striking effects on catalysis and nucleotide binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Altered thymidylate synthetase in 5-fluorodeoxyuridine-resistant ehrlich ascites carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Thymidylate synthase: a target for anticancer drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2'-deoxyuridylate and 10-propargyl-5,8-dideazafolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.40.25809

21 January 2018

Identifiers

DOI

10.1074/JBC.273.40.25809

1 reference

release_qtsaeu7tgzg67p7wqvethb53e4

5 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qtsaeu7tgzg67p7wqvethb53e4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference