(Q31115693)

29 June 2017

title

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design (English)

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29 June 2017

Matthew Bogyo

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29 June 2017

Doron C Greenbaum

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29 June 2017

William D Arnold

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29 June 2017

Felice Lu

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29 June 2017

Linda Hayrapetian

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29 June 2017

Amos Baruch

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29 June 2017

Jennifer Krumrine

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29 June 2017

Samuel Toba

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29 June 2017

Kareem Chehade

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29 June 2017

Dieter Brömme

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29 June 2017

Irwin D Kuntz

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29 June 2017

publication date

1 October 2002

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29 June 2017

published in

Chemistry and Biology

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29 June 2017

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29 June 2017

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29 June 2017

page(s)

1085-1094

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Protein function in the post-genomic era.

29 June 2017

cites work

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Method for prediction of protein function from sequence using the sequence-to-structure-to-function paradigm with application to glutaredoxins/thioredoxins and T1 ribonucleases

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7 January 2021

Latent semantic structure indexing (LaSSI) for defining chemical similarity

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7 January 2021

Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D.

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7 January 2021

Inhibitors of kinesin activity from structure-based computer screening

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7 January 2021

Molecular dynamics and free energy analyses of cathepsin D-inhibitor interactions: insight into structure-based ligand design

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7 January 2021

Affinity fingerprinting

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7 January 2021

Predicting ligand binding to proteins by affinity fingerprinting

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7 January 2021

Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era

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7 January 2021

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

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7 January 2021

Chemical approaches for functionally probing the proteome

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7 January 2021

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

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7 January 2021

Revised definition of substrate binding sites of papain-like cysteine proteases

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7 January 2021

Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors

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7 January 2021

Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors.

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7 January 2021

Cluster analysis and display of genome-wide expression patterns

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7 January 2021

E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group

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7 January 2021

Design, docking, and evaluation of multiple libraries against multiple targets

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7 January 2021

Calculating structures and free energies of complex molecules: combining molecular mechanics and continuum models

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7 January 2021

DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases

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7 January 2021

Crystal structure of human osteoclast cathepsin K complex with E-64

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7 January 2021

Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors

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7 January 2021

Crystal structure of human cathepsin V

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7 January 2021

Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.

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7 January 2021

A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease

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7 January 2021

Crystal structure of human cathepsin S.

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7 January 2021

Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs

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7 January 2021

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes

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7 January 2021

The Protein Data Bank

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7 January 2021

Comparison of simple potential functions for simulating liquid water

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7 January 2021

10.1016/S1074-5521(02)00238-7

Identifiers

DOI

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29 June 2017

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