(Q308856)

http://www.ebi.ac.uk/interpro/protein/P21917

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917

1 reference

27 February 2018

potassium channel regulator activity

1 reference

8 April 2019

G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

SH3 domain binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

protein binding

IntAct protein interaction database

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

IPI

8 April 2019

Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

IPI

8 April 2019

G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

dopamine neurotransmitter receptor activity, coupled via Gi/Go

IPI

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

ISS

8 April 2019

Palmitoylation of the carboxyl-terminal tail of dopamine D4 receptor is required for surface expression, endocytosis, and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

epinephrine binding

1 reference

8 April 2019

Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

norepinephrine binding

1 reference

8 April 2019

Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

1 reference

8 April 2019

G protein-coupled receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

G protein-coupled serotonin receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

neurotransmitter receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

integral component of plasma membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917

6 references

16 July 2018

16 July 2018

Palmitoylation of the carboxyl-terminal tail of dopamine D4 receptor is required for surface expression, endocytosis, and signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917

16 July 2018

Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917

16 July 2018

Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917

16 July 2018

Dopamine D4 receptors elevated in schizophrenia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21917&geneProductId=UniProtKB:P21917

plasma membrane

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

integral component of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

7 references

8 April 2019

8 April 2019

Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

Palmitoylation of the carboxyl-terminal tail of dopamine D4 receptor is required for surface expression, endocytosis, and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

Dopamine D4 receptors elevated in schizophrenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

dendrite

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

biological process

rhythmic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

1 reference

8 April 2019

arachidonic acid secretion

1 reference

8 April 2019

D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

positive regulation of dopamine uptake involved in synaptic transmission

1 reference

8 April 2019

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

1 reference

8 April 2019

dopamine metabolic process

1 reference

8 April 2019

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

behavioral response to ethanol

TAS

1 reference

8 April 2019

Olanzapine reduces craving for alcohol: a DRD4 VNTR polymorphism by pharmacotherapy interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

positive regulation of sodium:proton antiporter activity

TAS

1 reference

8 April 2019

D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

cellular calcium ion homeostasis

1 reference

8 April 2019

Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

positive regulation of kinase activity

1 reference

8 April 2019

Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

negative regulation of protein secretion

1 reference

8 April 2019

Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

negative regulation of voltage-gated calcium channel activity

1 reference

8 April 2019

Pharmacology of high-threshold calcium currents in GH4C1 pituitary cells and their regulation by activation of human D2 and D4 dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

response to histamine

1 reference

8 April 2019

Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

behavioral fear response

1 reference

8 April 2019

Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting dopamine receptor signaling pathway

TAS

Palmitoylation of the carboxyl-terminal tail of dopamine D4 receptor is required for surface expression, endocytosis, and signaling

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

dopamine receptor signaling pathway

1 reference

8 April 2019

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

regulation of postsynaptic neurotransmitter receptor internalization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

chemical synaptic transmission

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

G protein-coupled serotonin receptor signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21917

physically interacts with

1 reference

7683

17 August 2016

1 reference

941

17 August 2016

1 reference

3301

17 August 2016

1 reference

8439

17 August 2016

1 reference

940

17 August 2016

1 reference

939

17 August 2016

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

17 August 2016

1 reference

966

17 August 2016

1 reference

17 August 2016

1 reference

3303

17 August 2016

1 reference

205

English

5-chloro-2-methoxy-4-(methylamino)-N-(2-methyl-1-(phenylmethyl)-3-pyrrolidinyl)benzamide

17 August 2016

has use

1 reference

983

17 August 2016

1 reference

7556

17 August 2016

1 reference

17 August 2016

1 reference

7279

17 August 2016

1 reference

17 August 2016

1 reference

980

17 August 2016

1 reference

17 August 2016

1 reference

958

17 August 2016

1 reference

17 August 2016

1 reference

214

17 August 2016

1 reference

103

English

17 August 2016

pimozide

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1423

droperidol

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1108

haloperidol

inverse agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL54

apomorphine

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL53

thioridazine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200916

bromocriptine mesylate

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200503

chlorpromazine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1713

pergolide mesylate

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1275

promazine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200469

Gene Atlas image

PBB GE DRD4 208215 x at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P21917

1 reference

GPCR, rhodopsin-like, 7TM

Identifiers.org

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21917

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

28 October 2013

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023