(Q30871076)

27 June 2017

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title

Cancer risk and the ATM gene: a continuing debate (English)

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27 June 2017

Khanna KK

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27 June 2017

language of work or name

English

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publication date

1 May 2000

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Journal of the National Cancer Institute

27 June 2017

published in

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27 June 2017

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27 June 2017

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27 June 2017

page(s)

795-802

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The genetic defect in ataxia-telangiectasia

27 June 2017

cites work

1 reference

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Cancers in 44 families with ataxia-telangiectasia

21 January 2018

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Cancer in ataxia-telangiectasia patients

21 January 2018

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Breast and other cancers in families with ataxia-telangiectasia

21 January 2018

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Familial aggregation of a disease consequent upon correlation between relatives in a risk factor measured on a continuous scale

21 January 2018

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A single ataxia telangiectasia gene with a product similar to PI-3 kinase

21 January 2018

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Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype

21 January 2018

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Recombinant ATM protein complements the cellular A-T phenotype

21 January 2018

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The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage

21 January 2018

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Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms

21 January 2018

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21 January 2018

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Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase

21 January 2018

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ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia

21 January 2018

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

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Interaction between ATM protein and c-Abl in response to DNA damage

21 January 2018

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Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

21 January 2018

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The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.

21 January 2018

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c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl

21 January 2018

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The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

21 January 2018

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Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

21 January 2018

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In situ visualization of DNA double-strand break repair in human fibroblasts

21 January 2018

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Association of BRCA1 with Rad51 in mitotic and meiotic cells

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Ataxia-telangiectasia and the ATM gene: linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer

21 January 2018

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Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Heterozygous ATM mutations do not contribute to early onset of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

21 January 2018

1 reference

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Risk of breast cancer and other cancers in heterozygotes for ataxia-telangiectasia

21 January 2018

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Absence of mutations in the ATM gene in breast cancer patients with severe responses to radiotherapy

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Heterozygosity for mutations in the ataxia telangiectasia gene is not a major cause of radiotherapy complications in breast cancer patients

21 January 2018

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Testing for mutations of the ataxia telangiectasia gene in radiosensitive breast cancer patients

21 January 2018

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https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Ataxia-telangiectasia: identification and detection of founder-effect mutations in the ATM gene in ethnic populations

21 January 2018

1 reference

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A model for ATM heterozygote identification in a large population: four founder-effect ATM mutations identify most of Costa Rican patients with ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

ATM is usually rearranged in T-cell prolymphocytic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene

21 January 2018

1 reference

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Fragments of ATM which have dominant-negative or complementing activity

21 January 2018

1 reference

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Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

1 reference

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Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Germline p53 gene mutations and cancer--Pandora's box or open sesame?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Role of the p16 tumor suppressor gene in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

The Bloom's syndrome gene product is homologous to RecQ helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Cloning the gene for Werner syndrome: a disease with many symptoms of premature aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Keeping an old friend under control: regulation of p53 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

21 January 2018

The spindle checkpoint

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Feedback control of mitosis in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Mutations of mitotic checkpoint genes in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

A p53-dependent mouse spindle checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Sir-Ku-itous routes to make ends meet

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Accelerated telomere shortening in ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

Circular chromosome formation in a fission yeast mutant defective in two ATM homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F92.10.795

21 January 2018

Identifiers

DOI

10.1093/JNCI/92.10.795

1 reference

27 June 2017

1 reference