(Q30868363)

27 June 2017

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title

Streptavidin-binding and -dimerizing ligands discovered by phage display, topochemistry, and structure-based design (English)

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27 June 2017

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Katz BA

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27 June 2017

publication date

1 December 1999

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27 June 2017

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27 June 2017

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27 June 2017

issue

1-4

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27 June 2017

page(s)

57-65

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27 June 2017

cites work

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Engineered chimeric streptavidin tetramers as novel tools for bioseparations and drug delivery

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Engineering subunit association of multisubunit proteins: a dimeric streptavidin.

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Recombinant core streptavidins. A minimum-sized core streptavidin has enhanced structural stability and higher accessibility to biotinylated macromolecules.

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Streptavidins with intersubunit crosslinks have enhanced stability

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7 January 2021

Random peptide libraries: a source of specific protein binding molecules

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7 January 2021

Crystal structure and ligand-binding studies of a screened peptide complexed with streptavidin

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7 January 2021

An M13 phage library displaying random 38-amino-acid peptides as a source of novel sequences with affinity to selected targets

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7 January 2021

Antibody as a surrogate receptor in the screening of a phage display library

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7 January 2021

Biotin binders selected from a random peptide library expressed on phage

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Crystal structure of core streptavidin determined from multiwavelength anomalous diffraction of synchrotron radiation

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7 January 2021

Molecular interaction between the Strep-tag affinity peptide and its cognate target, streptavidin

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7 January 2021

Structural studies of the streptavidin binding loop

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7 January 2021

Intersubunit contacts made by tryptophan 120 with biotin are essential for both strong biotin binding and biotin-induced tighter subunit association of streptavidin

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7 January 2021

Site-directed mutagenesis studies of the high-affinity streptavidin-biotin complex: contributions of tryptophan residues 79, 108, and 120

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7 January 2021

Absolute and relative binding free energy calculations of the interaction of biotin and its analogs with streptavidin using molecular dynamics/free energy perturbation approaches

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7 January 2021

What determines the strength of noncovalent association of ligands to proteins in aqueous solution?

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7 January 2021

Screening of cyclic peptide phage libraries identifies ligands that bind streptavidin with high affinities

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7 January 2021

Binding to protein targets of peptidic leads discovered by phage display: crystal structures of streptavidin-bound linear and cyclic peptide ligands containing the HPQ sequence

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7 January 2021

In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0

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7 January 2021

Prediction of pH-dependent properties of proteins

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Classical electrostatics in biology and chemistry

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Theory of electrostatic interactions in macromolecules

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7 January 2021

The determinants of pKas in proteins

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7 January 2021

Calculations of electrostatic interactions in biological systems and in solutions

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7 January 2021

Nanometric design of extraordinary hydrophobic-induced pKa shifts for aspartic acid: relevance to protein mechanisms

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Electrostatic interactions in wild-type and mutant recombinant human myoglobins

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7 January 2021

In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core

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7 January 2021

Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme

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7 January 2021

Cyclic RGD peptide analogues as antiplatelet antithrombotics

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7 January 2021

Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH

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7 January 2021

Proximity versus allostery: the role of regulated protein dimerization in biology

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7 January 2021

Making agonists of antagonists

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7 January 2021

Cytokines and their receptor complexes.

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Dimerization of cell surface receptors in signal transduction

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7 January 2021

Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins

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7 January 2021

Rational design of potent antagonists to the human growth hormone receptor

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7 January 2021

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

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7 January 2021

Binding in the growth hormone receptor complex

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7 January 2021

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization

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7 January 2021

Small peptides as potent mimetics of the protein hormone erythropoietin

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7 January 2021

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

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7 January 2021

Topochemistry for preparing ligands that dimerize receptors

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7 January 2021

Functional analysis of a dominant negative mutant of G alpha i2.

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7 January 2021

The Occurence of C–H · · · O Hydrogen Bonds in Proteins

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7 January 2021

10.1016/S1050-3862(99)00036-4

Identifiers

DOI

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27 June 2017

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