(Q30840824)

27 June 2017

title

A new functional screening system for identification of regulators for the generation of amyloid beta-protein (English)

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27 June 2017

Hiroto Komano

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27 June 2017

Hirohisa Shiraishi

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27 June 2017

Yuuki Kawamura

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27 June 2017

Xiaorei Sai

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27 June 2017

Ryo Suzuki

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27 June 2017

Lutgarde Serneels

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27 June 2017

Masashi Kawaichi

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27 June 2017

Toshio Kitamura

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27 June 2017

Katsuhiko Yanagisawa

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27 June 2017

language of work or name

English

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publication date

2 August 2002

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Journal of Biological Chemistry

27 June 2017

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inferred from page(s)

published in

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27 June 2017

volume

277

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27 June 2017

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27 June 2017

page(s)

39627-39633

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Amyloid beta-protein and the genetics of Alzheimer's disease

27 June 2017

cites work

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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21 January 2018

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Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein

21 January 2018

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21 January 2018

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21 January 2018

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Secretion of Alzheimer beta/A4 protein (1-40) and intracellular retention of beta/A4 protein (1-42) in transfected COS cells

21 January 2018

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21 January 2018

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Neuronal expression of beta-amyloid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains

21 January 2018

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Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide

21 January 2018

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Dominant effector genetics in mammalian cells

21 January 2018

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Efficient screening of retroviral cDNA expression libraries

21 January 2018

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X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

21 January 2018

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Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein

21 January 2018

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21 January 2018

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Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein

21 January 2018

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Overexpression of Rab11 or constitutively active Rab11 does not affect sAPPalpha and Abeta secretions by wild-type and Swedish mutated betaAPP-expressing HEK293 cells.

21 January 2018

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Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

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Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

21 January 2018

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Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi

21 January 2018

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Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

21 January 2018

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Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

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Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

21 January 2018

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Rab1a and multiple other Rab proteins are associated with the transcytotic pathway in rat liver

21 January 2018

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Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

21 January 2018

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Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

21 January 2018

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Rab GTPases in vesicular transport

21 January 2018

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Long Amyloid .beta.-Protein Secreted from Wild-Type Human Neuroblastoma IMR-32 Cells

21 January 2018

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Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M205255200

1 reference

27 June 2017

1 reference