(Q30418378)

21 June 2017

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title

Mutations in the APC gene and their implications for protein structure and function (English)

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21 June 2017

Polakis P

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21 June 2017

publication date

1 February 1995

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Current Opinion in Genetics & Development

21 June 2017

published in

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21 June 2017

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21 June 2017

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21 June 2017

page(s)

66-71

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Identification and characterization of the familial adenomatous polyposis coli gene

21 June 2017

cites work

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Identification of FAP locus genes from chromosome 5q21

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Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

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Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

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APC mutations occur early during colorectal tumorigenesis

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Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas

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Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma

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7 January 2021

Mutations of the APC (adenomatous polyposis coli) gene

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Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients.

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Frequency of common and novel inactivating APC mutations in 202 families with familial adenomatous polyposis.

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7 January 2021

Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli.

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Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis.

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Alleles of the APC gene: an attenuated form of familial polyposis

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Identification of deletion mutations and three new genes at the familial polyposis locus

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Mutation in a splice-donor site of the APC gene in a family with polyposis and late age of colonic cancer death

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

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Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

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7 January 2021

Association of the APC gene product with beta-catenin

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7 January 2021

Association of the APC tumor suppressor protein with catenins

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From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

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Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion

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Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

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7 January 2021

Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells

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A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin

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A repeating amino acid motif shared by proteins with diverse cellular roles

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7 January 2021

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Identifiers

DOI

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21 June 2017

1 reference