(Q30312126)

16 June 2017

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title

Parsing the polarity code (English)

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16 June 2017

Ian G Macara

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16 June 2017

publication date

1 March 2004

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Nature Reviews Molecular Cell Biology

16 June 2017

published in

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16 June 2017

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16 June 2017

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16 June 2017

page(s)

220-231

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Identification of genes required for cytoplasmic localization in early C. elegans embryos

16 June 2017

cites work

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PARsing embryonic polarity

31 March 2020

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Cell Polarity and the Cytoskeleton in theCaenorhabditis ElegansZygote

31 March 2020

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Caenorhabditis elegans par genes

31 March 2020

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par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

31 March 2020

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Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos

31 March 2020

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The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo

31 March 2020

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par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs

31 March 2020

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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

31 March 2020

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An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3

31 March 2020

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Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

31 March 2020

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A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

31 March 2020

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A conserved oligomerization domain in drosophila Bazooka/PAR-3 is important for apical localization and epithelial polarity

31 March 2020

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Self-association of PAR-3-mediated by the Conserved N-terminal Domain Contributes to the Development of Epithelial Tight Junctions

31 March 2020

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A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

31 March 2020

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Phosphorylation-dependent binding of 14-3-3 to the polarity protein Par3 regulates cell polarity in mammalian epithelia.

31 March 2020

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Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells

31 March 2020

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LKB1 (XEEK1) regulates Wnt signalling in vertebrate development

31 March 2020

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CDC-42 controls early cell polarity and spindle orientation in C. elegans

31 March 2020

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CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans

31 March 2020

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Assembly of epithelial tight junctions is negatively regulated by Par6.

31 March 2020

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Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

31 March 2020

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31 March 2020

Two poles and a compass.

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Temporal and spatial regulation of chemotaxis

31 March 2020

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Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils

31 March 2020

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Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

31 March 2020

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Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils

31 March 2020

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Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity

31 March 2020

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PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.

31 March 2020

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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

31 March 2020

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Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

31 March 2020

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Regulated protein-protein interaction between aPKC and PAR-3 plays an essential role in the polarization of epithelial cells

31 March 2020

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Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties

31 March 2020

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31 March 2020

Tight junction proteins

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Claudin-based barrier in simple and stratified cellular sheets

31 March 2020

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Epithelial cell polarity and cell junctions in Drosophila

31 March 2020

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Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity

31 March 2020

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Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells

31 March 2020

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Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.

31 March 2020

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armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila.

31 March 2020

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The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost

31 March 2020

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The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions

31 March 2020

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Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)

31 March 2020

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hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells

31 March 2020

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The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells

31 March 2020

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Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

31 March 2020

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DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila

31 March 2020

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Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity.

31 March 2020

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Sticky business: orchestrating cellular signals at adherens junctions

31 March 2020

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Adherens junctions: new insight into assembly, modulation and function

31 March 2020

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Nectin and afadin: novel organizers of intercellular junctions.

31 March 2020

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Localization of apical epithelial determinants by the basolateral PDZ protein Scribble

31 March 2020

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Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors

31 March 2020

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Zonula adherens formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large

31 March 2020

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Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization.

31 March 2020

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Integrated activity of PDZ protein complexes regulates epithelial polarity

31 March 2020

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Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity

31 March 2020

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The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.

31 March 2020

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A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.

31 March 2020

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Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells

31 March 2020

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nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina

31 March 2020

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Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis

31 March 2020

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Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

31 March 2020

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Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization

31 March 2020

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mDia mediates Rho-regulated formation and orientation of stable microtubules

31 March 2020

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Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts

31 March 2020

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CLIP-170 highlights growing microtubule ends in vivo

31 March 2020

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Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170

31 March 2020

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LIS1, CLIP-170's key to the dynein/dynactin pathway

31 March 2020

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Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases

31 March 2020

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A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans

31 March 2020

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Myosin and the PAR proteins polarize microfilament-dependent forces that shape and position mitotic spindles in Caenorhabditis elegans

31 March 2020

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A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila

31 March 2020

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Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization

31 March 2020

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A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization

31 March 2020

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Selective interaction of AGS3 with G-proteins and the influence of AGS3 on the activation state of G-proteins

31 March 2020

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Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos

31 March 2020

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Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits

31 March 2020

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Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos

31 March 2020

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A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function inC. elegans

31 March 2020

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Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo

31 March 2020

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Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system

31 March 2020

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Distinct roles of Galphai and Gbeta13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions

31 March 2020

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LGN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation

31 March 2020

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Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression

31 March 2020

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MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

31 March 2020

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Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction

31 March 2020

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Anterior-posterior polarity in C. elegans and Drosophila--PARallels and differences

31 March 2020

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Asymmetric cell division in the Drosophila nervous system

31 March 2020

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Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts

31 March 2020

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Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts.

31 March 2020

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Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast

31 March 2020

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The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.

31 March 2020

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A role for Cdc42 in macrophage chemotaxis

31 March 2020

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Cdc42-dependent modulation of tight junctions and membrane protein traffic in polarized Madin-Darby canine kidney cells

31 March 2020

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Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42

31 March 2020

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Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1332

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Dimensions Publication ID

16 June 2017

1042316428

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