(Q29819495)

Numb/numb-like

1 reference

NUMB domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PTB/PI domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

1 reference

9 May 2019

Notch binding

1 reference

9 May 2019

Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

protein binding

5 references

9 May 2019

RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

9 May 2019

aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

9 May 2019

A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

9 May 2019

Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

9 May 2019

Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

1 reference

9 May 2019

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

1 reference

9 May 2019

cell cortex

1 reference

27 February 2018

Quantitative analysis of protein dynamics during asymmetric cell division

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

cytoplasm

Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

3 references

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

14 January 2019

Multiple signalling pathways establish cell fate and cell number in Drosophila malpighian tubules

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

basal part of cell

1 reference

9 May 2019

Mechanisms of spindle positioning: focus on flies and worms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

3 references

9 May 2019

9 May 2019

Multiple signalling pathways establish cell fate and cell number in Drosophila malpighian tubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

IBA

biological process

cell fate determination

1 reference

14 January 2019

Asymmetric localization and function of cell-fate determinants: a fly's view

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

Notch signaling pathway

1 reference

21 June 2018

Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

1 reference

9 May 2019

negative regulation of neuroblast proliferation

1 reference

9 May 2019

Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

central nervous system development

1 reference

9 May 2019

Protein localization during asymmetric cell division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

ventral cord development

1 reference

14 January 2019

Genetic control of Drosophila nerve cord development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

peripheral nervous system development

1 reference

27 February 2018

Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

heart development

1 reference

9 May 2019

Control of cardiac development by an evolutionarily conserved transcriptional network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

rhythmic behavior

1 reference

9 May 2019

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

protein localization

1 reference

9 May 2019

Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

glial cell migration

1 reference

9 May 2019

Notch and Numb are required for normal migration of peripheral glia in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

asymmetric cell division

Notch signaling: a dance of proteins changing partners

3 references

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Asymmetric localization and function of cell-fate determinants: a fly's view

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Genetic control of Drosophila nerve cord development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

regulation of Notch signaling pathway

1 reference

14 January 2019

Membrane trafficking in Drosophila wing and eye development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

regulation of asymmetric cell division

1 reference

9 May 2019

Ancestry-independent fate specification and plasticity in the developmental timing of a typical Drosophila neuronal lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

negative regulation of gene expression

1 reference

9 May 2019

Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

neuroblast development

1 reference

9 May 2019

The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

sensory organ precursor cell fate determination

Protein localization during asymmetric cell division

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

21 June 2018

Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

21 June 2018

Polarized endosome dynamics by spindle asymmetry during asymmetric cell division

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

embryonic heart tube development

1 reference

9 May 2019

Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

muscle cell fate specification

1 reference

9 May 2019

Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

sensory organ precursor cell division

1 reference

9 May 2019

Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

cell fate commitment

1 reference

9 May 2019

Control of cardiac development by an evolutionarily conserved transcriptional network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

negative regulation of Notch signaling pathway

5 references

21 June 2018

Notch signaling: a dance of proteins changing partners

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

21 June 2018

Asymmetric localization and function of cell-fate determinants: a fly's view

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

21 June 2018

Endocytosis in Drosophila: progress, possibilities, prognostications

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

21 June 2018

Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

21 June 2018

Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

positive regulation of endocytosis

1 reference

9 May 2019

Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

centrosome localization

1 reference

9 May 2019

Regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

regulation of nervous system development

1 reference

9 May 2019

Ancestry-independent fate specification and plasticity in the developmental timing of a typical Drosophila neuronal lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

pericardial nephrocyte differentiation

1 reference

9 May 2019

Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

Malpighian tubule tip cell differentiation

1 reference

9 May 2019

Multiple signalling pathways establish cell fate and cell number in Drosophila malpighian tubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

regulation of neuroblast proliferation

1 reference

9 May 2019

bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

negative regulation of receptor recycling

1 reference

9 May 2019

Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

sensory organ precursor cell fate determination

Protein localization during asymmetric cell division

4 references

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Polarized endosome dynamics by spindle asymmetry during asymmetric cell division

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

enteroendocrine cell differentiation

1 reference

9 May 2019

Intrinsic regulation of enteroendocrine fate by Numb.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

negative regulation of Notch signaling pathway

Asymmetric localization and function of cell-fate determinants: a fly's view

8 references

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Endocytosis in Drosophila: progress, possibilities, prognostications

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Notch signaling: a dance of proteins changing partners

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Intrinsic regulation of enteroendocrine fate by Numb.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

14 January 2019

Numb antagonizes Notch signaling to specify sibling neuron cell fates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16554&geneProductId=UniProtKB:P16554

neuroblast fate determination

1 reference

9 May 2019

Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

negative regulation of Notch signaling pathway

Numb proteins specify asymmetric cell fates via an endocytosis- and proteasome-independent pathway.

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

9 May 2019

Sanpodo: a context-dependent activator and inhibitor of Notch signaling during asymmetric divisions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

9 May 2019

Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

9 May 2019

Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

9 May 2019

Numb antagonizes Notch signaling to specify sibling neuron cell fates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

9 May 2019

Intrinsic regulation of enteroendocrine fate by Numb.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

asymmetric neuroblast division

1 reference

9 May 2019

Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16554

1 reference

NUMB domain

1 reference