(Q29818468)

Winged helix-like DNA-binding domain superfamily

1 reference

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Paired domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II transcription regulatory region sequence-specific DNA binding

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

2 references

protein binding

3 references

8 April 2019

distal antenna and distal antenna-related function in the retinal determination network during eye development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

8 April 2019

Cross-regulatory protein-protein interactions between Hox and Pax transcription factors

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

8 April 2019

Direct control of neurogenesis by selector factors in the fly eye: regulation of atonal by Ey and So.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

DNA-binding transcription factor activity, RNA polymerase II-specific

transcription, DNA-templated

biological process

http://www.ebi.ac.uk/QuickGO/annotations?protein=O18381&geneProductId=UniProtKB:O18381

1 reference

27 March 2018

regulation of transcription, DNA-templated

IEA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

1 reference

8 April 2019

regulation of transcription by RNA polymerase II

IEA

1 reference

8 April 2019

Transcriptional activities of the Pax6 gene eyeless regulate tissue specificity of ectopic eye formation in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

1 reference

8 April 2019

IEA

brain development

1 reference

8 April 2019

Drosophila Pax-6/eyeless is essential for normal adult brain structure and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

eye-antennal disc morphogenesis

TAS

1 reference

8 April 2019

The retinal determination gene, dachshund, is required for mushroom body cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

TAS

adult walking behavior

1 reference

8 April 2019

Drosophila Pax-6/eyeless is essential for normal adult brain structure and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

positive regulation of cell population proliferation

1 reference

8 April 2019

The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

glial cell migration

1 reference

8 April 2019

Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

mushroom body development

Brain patterning defects caused by mutations of the twin of eyeless gene in Drosophila melanogaster

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

8 April 2019

Drosophila Pax-6/eyeless is essential for normal adult brain structure and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

8 April 2019

Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

8 April 2019

Early development of the Drosophila mushroom body: the roles of eyeless and dachshund.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

8 April 2019

Early development of the Drosophila mushroom body: the roles of eyeless and dachshund.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

IEP

neuron differentiation

1 reference

8 April 2019

Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

positive regulation of cell growth

1 reference

8 April 2019

The homeodomain of Eyeless regulates cell growth and antagonizes the paired domain-dependent retinal differentiation function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

positive regulation of multicellular organism growth

1 reference

8 April 2019

Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

regulation of insulin-like growth factor receptor signaling pathway

1 reference

8 April 2019

Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

photoreceptor cell fate specification

1 reference

8 April 2019

Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

positive regulation of transcription by RNA polymerase II

Conserved role for the Drosophila Pax6 homolog Eyeless in differentiation and function of insulin-producing neurons.

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

8 April 2019

Functional analysis of the chicken delta1-crystallin enhancer activity in Drosophila reveals remarkable evolutionary conservation between chicken and fly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

8 April 2019

Eyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

central complex development

1 reference

8 April 2019

Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

brain morphogenesis

1 reference

8 April 2019

Brain patterning defects caused by mutations of the twin of eyeless gene in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

glucose homeostasis

1 reference

8 April 2019

Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O18381

has part(s)

Homeobox, conserved site

1 reference

Homeobox domain

1 reference

Paired domain

1 reference