(Q29811609)

PAS domain superfamily

1 reference

Helix-loop-helix DNA-binding domain superfamily

1 reference

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PAC motif domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PAS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

8 April 2019

PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

DNA binding

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

8 April 2019

PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

chromatin binding

1 reference

8 April 2019

A Screening of UNF Targets Identifies Rnb, a Novel Regulator of Drosophila Circadian Rhythms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

DNA-binding transcription factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

1 reference

8 April 2019

protein binding

4 references

8 April 2019

The CK2 kinase stabilizes CLOCK and represses its activity in the Drosophila circadian oscillator

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Cytoplasmic interaction with CYCLE promotes the post-translational processing of the circadian CLOCK protein

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

transcription factor binding

1 reference

8 April 2019

PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

protein heterodimerization activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Cytoplasmic interaction with CYCLE promotes the post-translational processing of the circadian CLOCK protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

1 reference

8 April 2019

cell component

nucleus

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

1 reference

8 April 2019

transcription regulator complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

1 reference

8 April 2019

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

1 reference

8 April 2019

CLOCK-BMAL transcription complex

1 reference

8 April 2019

Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

negative regulation of transcription by RNA polymerase II

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

circadian regulation of heart rate

1 reference

8 April 2019

Time-restricted feeding attenuates age-related cardiac decline in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=O61735&geneProductId=UniProtKB:O61735

1 reference

16 July 2018

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

1 reference

8 April 2019

rhythmic behavior

1 reference

8 April 2019

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

circadian rhythm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

12 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Central and peripheral circadian oscillator mechanisms in flies and mammals.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Circadian rhythms from flies to human

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

8 April 2019

Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Drosophila: genetics meets behaviour.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Drosophila clock can generate ectopic circadian clocks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

response to temperature stimulus

1 reference

27 February 2018

Phosphorylation of a central clock transcription factor is required for thermal but not photic entrainment.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O61735&geneProductId=UniProtKB:O61735

entrainment of circadian clock

1 reference

8 April 2019

Phosphorylation of a central clock transcription factor is required for thermal but not photic entrainment.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

circadian regulation of gene expression

3 references

8 April 2019

Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABAA Receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

negative regulation of apoptotic process

1 reference

8 April 2019

Drosophila spaghetti and doubletime link the circadian clock and light to caspases, apoptosis and tauopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

regulation of circadian sleep/wake cycle, sleep

1 reference

8 April 2019

Stress response genes protect against lethal effects of sleep deprivation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

locomotor rhythm

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Drosophila: genetics meets behaviour.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Drosophila clock can generate ectopic circadian clocks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

positive regulation of transcription, DNA-templated

Central and peripheral circadian oscillator mechanisms in flies and mammals.

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Circadian rhythms from flies to human

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

IGI

8 April 2019

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

positive regulation of transcription by RNA polymerase II

IGI

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABAA Receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

8 April 2019

Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

rhythmic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

1 reference

8 April 2019

response to temperature stimulus

response to light stimulus

1 reference

8 April 2019

Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

1 reference

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

PAS domain

1 reference