(Q29798158)

Apoptosis regulator, Ced-4

1 reference

Death-like domain superfamily

1 reference

P-loop containing nucleoside triphosphate hydrolase

1 reference

Winged helix-like DNA-binding domain superfamily

1 reference

CARD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NB-ARC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Caenorhabditis elegans

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 reference

1 January 2018

protein binding

14 references

1 January 2018

Mutational analysis of the interacting cell death regulators CED-9 and CED-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

E1B 19,000-molecular-weight protein interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Interaction and regulation of subcellular localization of CED-4 by CED-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Interaction and regulation of subcellular localization of CED-4 by CED-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Matefin/SUN-1 is a nuclear envelope receptor for CED-4 during Caenorhabditis elegans apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Interaction between the C. elegans cell-death regulators CED-9 and CED-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

ATP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

4 references

1 January 2018

1 January 2018

Subcellular localization, oligomerization, and ATP-binding of Caenorhabditis elegans CED-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Role of CED-4 in the activation of CED-3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

cysteine-type endopeptidase activator activity involved in apoptotic process

Mechanistic insights into CED-4-mediated activation of CED-3

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

peptidase activator activity involved in apoptotic process

1 reference

1 January 2018

Role of CED-4 in the activation of CED-3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

ADP binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 reference

1 January 2018

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 reference

1 January 2018

BH1 domain binding

1 reference

1 January 2018

E1B 19,000-molecular-weight protein interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

BH3 domain binding

1 reference

1 January 2018

E1B 19,000-molecular-weight protein interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

endopeptidase activator activity

1 reference

1 January 2018

Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

caspase binding

1 reference

1 January 2018

Mechanistic insights into CED-4-mediated activation of CED-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

cell component

nucleus

1 reference

1 January 2018

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 reference

1 January 2018

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

3 references

1 January 2018

1 January 2018

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

cytosol

3 references

1 January 2018

Interaction and regulation of subcellular localization of CED-4 by CED-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

E1B 19,000-molecular-weight protein interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Interaction and regulation of subcellular localization of CED-4 by CED-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

caspase complex

1 reference

1 January 2018

Mechanistic insights into CED-4-mediated activation of CED-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

membrane

1 reference

1 January 2018

Interaction and regulation of subcellular localization of CED-4 by CED-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

perinuclear region of cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

5 references

1 January 2018

1 January 2018

Nonapoptotic role for Apaf-1 in the DNA damage checkpoint

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Interaction and regulation of subcellular localization of CED-4 by CED-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

E1B 19,000-molecular-weight protein interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

biological process

apoptotic process

The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

activation of cysteine-type endopeptidase activity involved in apoptotic process

Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14.

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

regulation of cell size

1 reference

1 January 2018

ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30429&geneProductId=UniProtKB:P30429

1 reference

31 January 2018

embryo development ending in birth or egg hatching

IBA

1 reference

1 January 2018

Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

positive regulation of protein processing

actin filament depolymerization

1 reference

1 January 2018

The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

regulation of cell adhesion

1 reference

1 January 2018

Programmed elimination of cells by caspase-independent cell extrusion in C. elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

regulation of protein stability

1 reference

1 January 2018

Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

regulation of development, heterochronic

1 reference

1 January 2018

CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 reference

1 January 2018

negative regulation of apoptotic process

1 reference

31 January 2018

An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30429&geneProductId=UniProtKB:P30429

regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

1 January 2018

E1B 19,000-molecular-weight protein interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

muscle cell cellular homeostasis

1 reference

1 January 2018

Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

embryonic morphogenesis

1 reference

1 January 2018

Autophagy and apoptosis are redundantly required for C. elegans embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

protein homotetramerization

1 reference

1 January 2018

Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

activation of cysteine-type endopeptidase activity

1 reference

1 January 2018

Mechanistic insights into CED-4-mediated activation of CED-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

apoptotic process involved in development

1 reference

1 January 2018

Programmed elimination of cells by caspase-independent cell extrusion in C. elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

positive regulation of apoptotic process involved in development

Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 January 2018

Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

positive regulation of synapse pruning

positive regulation of cysteine-type endopeptidase activity

1 reference

1 January 2018

Role of CED-4 in the activation of CED-3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30429

1 reference

CARD domain

1 reference