(Q288705)

Glycoside hydrolase, family 27

1 reference

TIM barrel

1 reference

glycosyl hydrolase, all-beta

1 reference

alpha galactosidase family

1 reference

based on heuristic

inferred from protein domain or family

Glycoside hydrolase family 27/36, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image of molecular model or crystal lattice model

PBB Protein GLA image.jpg
500 × 500; 52 KB

depicts

ribbon diagram

0 references

defined daily dose

1 milligram

route of administration

parenteral route of administration

1 reference

https://www.whocc.no/atc_ddd_index/?code=A16AB03

1 reference

18 July 2018

1 reference

18 July 2018

hydrolase activity, hydrolyzing O-glycosyl compounds

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

1 reference

8 April 2019

protein homodimerization activity

1 reference

8 April 2019

Affinity purification of alpha-galactosidase A from human spleen, placenta, and plasma with elimination of pyrogen contamination. Properties of the purified splenic enzyme compared to other forms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

hydrolase activity, acting on glycosyl bonds

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

1 reference

8 April 2019

raffinose alpha-galactosidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

1 reference

8 April 2019

protein binding

IPI

galactoside binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

signaling receptor binding

1 reference

8 April 2019

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

alpha-galactosidase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

6 references

26 September 2017

26 September 2017

Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

26 September 2017

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

26 September 2017

Studies on human liver alpha-galactosidases. I. Purification of alpha-galactosidase A and its enzymatic properties with glycolipid and oligosaccharide substrates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

26 September 2017

A novel mutation of α-galactosidase A gene causes Fabry disease mimicking primary erythromelalgia in a Chinese family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

alpha-galactosidase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

7 references

1 January 2018

1 January 2018

Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

1 January 2018

A novel mutation of α-galactosidase A gene causes Fabry disease mimicking primary erythromelalgia in a Chinese family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

1 January 2018

Studies on human liver alpha-galactosidases. I. Purification of alpha-galactosidase A and its enzymatic properties with glycolipid and oligosaccharide substrates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

alpha-galactosidase activity

Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

8 April 2019

Studies on human liver alpha-galactosidases. I. Purification of alpha-galactosidase A and its enzymatic properties with glycolipid and oligosaccharide substrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

8 April 2019

A novel mutation of α-galactosidase A gene causes Fabry disease mimicking primary erythromelalgia in a Chinese family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

cell component

cytoplasm

1 reference

26 September 2017

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

Golgi apparatus

1 reference

8 April 2019

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

lysosomal lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

1 reference

8 April 2019

lysosome

Synthesis and processing of alpha-galactosidase A in human fibroblasts. Evidence for different mutations in Fabry disease

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

8 April 2019

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

extracellular exosome

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

3 references

8 April 2019

8 April 2019

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

8 April 2019

Synthesis and processing of alpha-galactosidase A in human fibroblasts. Evidence for different mutations in Fabry disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

azurophil granule lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

1 reference

8 April 2019

cytoplasm

extracellular exosome

HDA

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

negative regulation of nitric-oxide synthase activity

HDA

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

1 reference

8 April 2019

glycosphingolipid metabolic process

ISS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

1 reference

8 April 2019

glycosphingolipid catabolic process

1 reference

8 April 2019

Alpha-galactosidase A gene rearrangements causing Fabry disease. Identification of short direct repeats at breakpoints in an Alu-rich gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

negative regulation of nitric oxide biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

1 reference

8 April 2019

ISS

metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

1 reference

8 April 2019

oligosaccharide metabolic process

1 reference

26 September 2017

Studies on human liver alpha-galactosidases. I. Purification of alpha-galactosidase A and its enzymatic properties with glycolipid and oligosaccharide substrates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P06280&geneProductId=UniProtKB:P06280

neutrophil degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

1 reference

8 April 2019

glycoside catabolic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

carbohydrate metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06280

1 reference

8 April 2019

oligosaccharide metabolic process

physically interacts with

Viroporin 3a

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

BioGRID

migalastat

object of statement has role

stabilizer

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL110458

Gene Atlas image

PBB GE GLA 214430 at fs.png
732 × 530; 11 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P06280

1 reference

Glycoside hydrolase family 27/36, conserved site

Identifiers.org

has part(s)

1 reference

Alpha galactosidase A, C-terminal beta-sandwich domain

1 reference

Identifiers

0 references

1 reference

18 May 2018

1 reference

18 July 2018

1 reference

1 reference

Microsoft Academic ID

0 references

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

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4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016