(Q28594828)

1 February 2017

title

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice (English)

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1 February 2017

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GOA release 2020-03-11

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I. Dragatsis

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1 February 2017

M. S. Levine

series ordinal

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1 February 2017

S. Zeitlin

series ordinal

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1 February 2017

language of work or name

English

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publication date

1 November 2000

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1 February 2017

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1 February 2017

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1 February 2017

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1 February 2017

page(s)

300–306

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Recent advances in understanding the pathogenesis of Huntington's disease

1 February 2017

cites work

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7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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7 January 2021

Huntington's disease gene (IT15) is widely expressed in human and rat tissues

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7 January 2021

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

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7 January 2021

Widespread expression of Huntington's disease gene (IT15) protein product

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7 January 2021

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

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7 January 2021

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

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7 January 2021

Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum.

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7 January 2021

Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways

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7 January 2021

Huntington's disease: translating a CAG repeat into a pathogenic mechanism

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7 January 2021

Inactivation of the mouse Huntington's disease gene homolog Hdh

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7 January 2021

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

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7 January 2021

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

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7 January 2021

Neuronal degeneration in the basal ganglia and loss of pallido-subthalamic synapses in mice with targeted disruption of the Huntington's disease gene

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7 January 2021

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1

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7 January 2021

CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

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7 January 2021

Subregion- and cell type-restricted gene knockout in mouse brain

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7 January 2021

Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes

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7 January 2021

Motor abnormalities in weaver mutant mice

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7 January 2021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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7 January 2021

In vivo hypoxia-induced neuronal damage with an enhancement of neuronal nitric oxide synthase immunoreactivity in hippocampus

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7 January 2021

Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

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7 January 2021

Early effects of intrastriatal injections of quinolinic acid on microtubule-associated protein-2 and neuropeptides in rat basal ganglia

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7 January 2021

A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor

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7 January 2021

Neurite outgrowth in response to transfected N-CAM changes during development and is modulated by polysialic acid

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7 January 2021

Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

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7 January 2021

Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival.

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7 January 2021

An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension

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7 January 2021

Distinct roles for adhesion molecules during innervation of embryonic chick muscle

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7 January 2021

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

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7 January 2021

Life without huntingtin: normal differentiation into functional neurons

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7 January 2021

Fast transport and retrograde movement of huntingtin and HAP 1 in axons

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7 January 2021

Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease

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7 January 2021

A molecular investigation of true dominance in Huntington's disease

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7 January 2021

Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

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7 January 2021

Disassembly of nuclear inclusions in the dividing cell--a novel insight into neurodegeneration

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7 January 2021

Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse.

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7 January 2021

SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

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7 January 2021

Formation of polyglutamine inclusions in non-CNS tissue

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7 January 2021

CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain

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7 January 2021

Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat.

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7 January 2021

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests

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7 January 2021

Wild-type huntingtin protects from apoptosis upstream of caspase-3.

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7 January 2021