(Q28589352)

31 January 2017

title

The role of Asp-462 in regulating Akt activity (English)

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31 January 2017

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GOA release 2020-03-11

Caspase 3

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Thymoma viral proto-oncogene 1

GOA release 2020-03-11

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GOA release 2020-03-11

Jun Xu

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31 January 2017

Dan Liu

series ordinal

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31 January 2017

Zhou Songyang

series ordinal

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31 January 2017

language of work or name

English

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publication date

20 September 2002

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Journal of Biological Chemistry

31 January 2017

published in

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31 January 2017

volume

277

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31 January 2017

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31 January 2017

page(s)

35561–35566

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Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

31 January 2017

cites work

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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PI3K: downstream AKTion blocks apoptosis

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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Cellular survival: a play in three Akts

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

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Interleukin 3-dependent survival by the Akt protein kinase

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Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

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Mechanisms and consequences of activation of protein kinase B/Akt

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Ten years of protein kinase B signalling: a hard Akt to follow

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PDK2: a complex tail in one Akt.

21 January 2018

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Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

21 January 2018

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Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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Regulation of cell death protease caspase-9 by phosphorylation

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Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis

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21 January 2018

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Production of high-titer helper-free retroviruses by transient transfection

21 January 2018

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

21 January 2018

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Role of translocation in the activation and function of protein kinase B

21 January 2018

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The dynamics of protein kinase B regulation during B cell antigen receptor engagement

21 January 2018

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Mechanism of activation and function of protein kinase B.

21 January 2018

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The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

21 January 2018

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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

21 January 2018

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Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M203805200

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31 January 2017

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