(Q28513655)

25 January 2017

title

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells (English)

1 reference

25 January 2017

main subject

DNA cross-link repair 1C

1 reference

GOA release 2020-03-11

JoAnn Sekiguchi

0 references

David Lombard

0 references

Sean Rooney

1 reference

25 January 2017

Frederick W. Alt

1 reference

25 January 2017

Scott Whitlow

1 reference

25 January 2017

Mark Eckersdorff

1 reference

25 January 2017

James Fleming

1 reference

25 January 2017

Sebastian Fugmann

1 reference

25 January 2017

David O. Ferguson

1 reference

25 January 2017

David G. Schatz

1 reference

25 January 2017

language of work or name

English

0 references

publication date

3 March 2003

1 reference

Journal of Experimental Medicine

25 January 2017

published in

1 reference

25 January 2017

volume

197

1 reference

25 January 2017

1 reference

25 January 2017

page(s)

553–565

1 reference

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

25 January 2017

cites work

1 reference

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19 March 2017

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Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

19 March 2017

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

19 March 2017

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Strand-Specific Postreplicative Processing of Mammalian Telomeres

19 March 2017

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DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway

19 March 2017

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Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C

19 March 2017

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The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations

19 March 2017

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19 March 2017

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DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

19 March 2017

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Ku is associated with the telomere in mammals

19 March 2017

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

19 March 2017

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Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

19 March 2017

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

19 March 2017

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Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

19 March 2017

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Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

19 March 2017

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

19 March 2017

1 reference

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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence

19 March 2017

1 reference

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Protection of mammalian telomeres

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Sensing and repairing DNA double-strand breaks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

The mechanism and regulation of chromosomal V(D)J recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Ku86 is essential in human somatic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

DNA-PKcs is critical for telomere capping

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

DNA double strand break repair and chromosomal translocation: lessons from animal models

29 September 2017

1 reference

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SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Ku acts in a unique way at the mammalian telomere to prevent end joining

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Analysis of ku80-mutant mice and cells with deficient levels of p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Gamma-irradiation directly affects the formation of coding joints in SCID cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

DNA hairpin opening mediated by the RAG1 and RAG2 proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Hairpin coding end opening is mediated by RAG1 and RAG2 proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Ku70: a candidate tumor suppressor gene for murine T cell lymphoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Multicolour spectral karyotyping of mouse chromosomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Increased radiosensitivity of granulocyte macrophage colony-forming units and skin fibroblasts in human autosomal recessive severe combined immunodeficiency

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Wild-type V(D)J recombination in scid pre-B cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

2 June 2018

1 reference

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Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Impairment of V(D)J recombination in double-strand break repair mutants

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Aberrant immunoglobulin gene rearrangement in scid mouse bone marrow cells

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells

2 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20021891

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20021891

P nucleotides, hairpin DNA and V(D)J joining: making the connection

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20021891

A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p

21 January 2018

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https://api.crossref.org/works/10.1084%2FJEM.20021891

21 January 2018

12 December 2020

DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193825

Coding joint formation of endogenous T cell receptor genes in lymphoid cells from scid mice: unusual P-nucleotide additions in VJ-coding joints

27 November 2018

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12 December 2020

T-lymphocyte development in scid mice is arrested shortly after the initiation of T-cell receptor delta gene recombination

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12 December 2020

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

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12 December 2020

Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

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12 December 2020

Lack of detectable defect in DNA double-strand break repair and DNA-dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts

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12 December 2020

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

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12 December 2020

The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement

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12 December 2020

Identifiers

DOI

10.1084/JEM.20021891

1 reference

1 reference

1 reference

1 reference