(Q28474747)

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The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells

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The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells (English)

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author name string

Gian Carlo Alghisi

1

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Lionel Ponsonnet

2

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Curzio Rüegg

3

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publication date

2009

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4

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2

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e4449

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Creative Commons Attribution 4.0 International

12 February 2009

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April 2022 Public Data File from Crossref

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Src kinase activation by direct interaction with the integrin β cytoplasmic domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

19 March 2017

Integrins: bidirectional, allosteric signaling machines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

19 March 2017

Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

19 March 2017

Integrin binding to fibronectin and vitronectin maintains the barrier function of isolated porcine coronary venules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

19 March 2017

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

19 March 2017

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

19 March 2017

Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

19 March 2017

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

7 April 2017

Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

The role of adherens junctions and VE-cadherin in the control of vascular permeability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

The integrin antagonist cilengitide increases the antitumor activity of temozolomide against malignant melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Purification, analysis, and crystal structure of integrins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Cell-matrix adhesion in vascular development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Possible involvement of integrin-mediated signalling in oocyte activation: evidence that a cyclic RGD-containing peptide can stimulate protein kinase C and cortical granule exocytosis in mouse oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Integrin alpha v beta 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Vascular integrins in tumor angiogenesis: mediators and therapeutic targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

The interplay between Src and integrins in normal and tumor biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Endothelial cell-cell junctions: happy together

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Cilengitide Merck

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Inhibition of the alpha-nu integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

Trans-dominant inhibition of integrin function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

29 September 2017

An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

2 June 2018

Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

2 June 2018

alphav beta 3 and alphav beta 5 integrin antagonists inhibit angiogenesis in vitro.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004449

21 January 2018

Distinctive role of integrin-mediated adhesion in TNF-induced PKB/Akt and NF-kappaB activation and endothelial cell survival.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004449

21 January 2018

Cilengitide (EMD 121974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004449

21 January 2018

Integrin-mediated adhesion and soluble ligand binding stabilize COX-2 protein levels in endothelial cells by inducing expression and preventing degradation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004449

21 January 2018

Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004449

21 January 2018

Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004449

21 January 2018

Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004449

21 January 2018

Competition for talin results in trans-dominant inhibition of integrin activation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004449

21 January 2018

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004449

21 January 2018

Integrin ligands mobilize Ca2+ from ryanodine receptor-gated stores and lysosome-related acidic organelles in pulmonary arterial smooth muscle cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004449

21 January 2018

Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0004449

21 January 2018

Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

27 November 2018

Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2636874

27 November 2018

Manganese-induced integrin affinity maturation promotes recruitment of alpha V beta 3 integrin to focal adhesions in endothelial cells: evidence for a role of phosphatidylinositol 3-kinase and Src

1 reference

https://pubmed.ncbi.nlm.nih.gov/19212436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19212436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrin inhibitors reaching the clinic

1 reference

https://pubmed.ncbi.nlm.nih.gov/19212436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cilengitide inhibits proliferation and differentiation of human endothelial progenitor cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19212436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19212436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arg-Gly-Asp peptide increases endothelial hydraulic conductivity: comparison with thrombin response

1 reference

https://pubmed.ncbi.nlm.nih.gov/19212436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Conformational changes of the platelet membrane glycoprotein IIb-IIIa complex stimulated by a monoclonal antibody to the N-terminal segment of glycoprotein IIIa]

1 reference

https://pubmed.ncbi.nlm.nih.gov/19212436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19212436

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0004449

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2009PLoSO...4.4449A

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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