(Q28306498)

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The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR

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The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR (English)

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author name string

S R Brand

1

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R Kobayashi

2

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M B Mathews

3

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publication date

28 March 1997

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Journal of Biological Chemistry

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272

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13

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8388-95

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Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

The trans-activator gene of the human T cell lymphotropic virus type III is required for replication

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Modulation of interferon-mediated inhibition of human immunodeficiency virus type 1 by Tat.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Repression of MHC class I gene promoter activity by two-exon Tat of HIV

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear events

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Phosphorylation of initiation factor elF-2 and the control of reticulocyte protein synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Translational control in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Partial characterization of a cellular factor that regulates the double-stranded RNA-dependent eIF-2 alpha kinase in 3T3-F442A fibroblasts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Isolation of a cellular protein that binds to the human immunodeficiency virus Tat protein and can potentiate transactivation of the viral promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Direct interaction of human TFIID with the HIV-1 transactivator tat

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

HIV-1 Tat protein trans-activates transcription in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Use of T7 RNA polymerase to direct expression of cloned genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Cellular uptake of the tat protein from human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Removal of double-stranded contaminants from RNA transcripts: synthesis of adenovirus VA RNAI from a T7 vector

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Another version of the human insulin receptor kinase domain: expression, purification, and characterization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: a novel translational control mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Tat-responsive region RNA of human immunodeficiency virus type 1 stimulates protein synthesis in vivo and in vitro: relationship between structure and function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Direct evidence for translational regulation by leader RNA and Tat protein of human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Inhibition of the dsRNA-dependent protein kinase by a peptide derived from the human immunodeficiency virus type 1 Tat protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

HIV-1 Tat Overcomes Inefficient Transcriptional Elongation in Vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

The phosphorylation of proteins: a major mechanism for biological regulation. Fourteenth Sir Frederick Gowland Hopkins memorial lecture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

The double-stranded RNA-dependent protein kinase is also activated by heparin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Two interferon-induced proteins are involved in the protein kinase complex dependent on double-stranded RNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Mechanism of interferon action: RNA-binding activity of full-length and R-domain forms of the RNA-dependent protein kinase PKR--determination of KD values for VAI and TAR RNAs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

Binding of NF-kB to the HIV-1 LTR is not sufficient to induce HIV-1 LTR activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.13.8388

21 January 2018

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