(Q28293996)

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Cell-cycle checkpoints and cancer

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Europe PubMed Central

Cell-cycle checkpoints and cancer (English)

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cell cycle checkpoint signaling

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Jiri Bartek

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Michael B Kastan

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18 November 2004

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432

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7015

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316-23

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

ATR and ATRIP: partners in checkpoint signaling

1 reference

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21 April 2017

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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21 April 2017

Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities

1 reference

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21 April 2017

Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

1 reference

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21 April 2017

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

1 reference

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21 April 2017

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

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21 April 2017

MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes

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21 April 2017

Claspin, a regulator of Chk1 in DNA replication stress pathway

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21 April 2017

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

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https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

MDC1 is required for the intra-S-phase DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

MDC1 is a mediator of the mammalian DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

The BRCT Domain Is a Phospho-Protein Binding Domain

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https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

Megabase chromatin domains involved in DNA double-strand breaks in vivo

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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21 April 2017

Regulating mammalian checkpoints through Cdc25 inactivation

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https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

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21 April 2017

Interaction of FANCD2 and NBS1 in the DNA damage response

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21 April 2017

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

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https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

Cancer susceptibility and the functions of BRCA1 and BRCA2

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

1 reference

https://api.crossref.org/works/10.1038/NATURE03097

21 April 2017

ATM and related protein kinases: safeguarding genome integrity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

21 April 2017

Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

21 April 2017

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

21 April 2017

Biallelic inactivation of BRCA2 in Fanconi anemia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

21 April 2017

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Checkpoints: controls that ensure the order of cell cycle events

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

ATM: genome stability, neuronal development, and cancer cross paths

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement of the MRN complex for ATM activation by DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

The Mre11 complex is required for ATM activation and the G2/M checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

53BP1, an activator of ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Checking on the fork: the DNA-replication stress-response pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

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Opening of the clamp: an intimate view of an ATP-driven biological machine.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

ATR and ATM regulate the timing of DNA replication origin firing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

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Hypoxia links ATR and p53 through replication arrest

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Chk1 and Chk2 kinases in checkpoint control and cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

53BP1, a mediator of the DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

The cellular response to DNA double-strand breaks: defining the sensors and mediators

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

The retinoblastoma protein pathway in cell cycle control and cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

The RB and p53 pathways in cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

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Checking on DNA damage in S phase

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

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The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Toward maintaining the genome: DNA damage and replication checkpoints

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of the G2/M transition by p53.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

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Targeting the checkpoint kinases: chemosensitization versus chemoprotection

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https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

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Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Chromosome instability induced in vitro with mitomycin C in five Seckel syndrome patients.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Checkpoint mediators: relaying signals from DNA strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

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Collaboration of Brca1 and Chk2 in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

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Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

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The Fanconi road to cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

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Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

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Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE03097

7 January 2021

based on heuristic

inferred from DOI database lookup

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