(Q28290100)

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Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor

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Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor (English)

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author name string

S Okada

1

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J E Pessin

2

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language of work or name

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publication date

11 October 1996

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Journal of Biological Chemistry

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271

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41

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25533-8

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

The function of GRB2 in linking the insulin receptor to Ras signaling pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation

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https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Divergent mechanisms for homologous desensitization of p21ras by insulin and growth factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Insulin-stimulated disassociation of the SOS-Grb2 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Binding of NCK to SOS and activation of ras-dependent gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors

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https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Functional Roles for the Pleckstrin and Dbl Homology Regions in the Ras Exchange Factor Son-of-sevenless

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

The Grb2 binding domain of mSos1 is not required for downstream signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

In vivo functional analysis of the Ras exchange factor son of sevenless

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Two species of human CRK cDNA encode proteins with distinct biological activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Epidermal Growth Factor Receptor Targeting Prevents Uncoupling of the Grb2-SOS Complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.41.25533

21 January 2018

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10.1074/JBC.271.41.25533

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