(Q28241772)

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J Brown

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F Crawford

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L Fidani

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L Giuffra

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A Haynes

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N Irving

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L James

The genetic defect causing familial Alzheimer's disease maps on chromosome 21.

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language of work or name

English

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publication date

21 February 1991

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published in

Nature

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volume

349

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issue

6311

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page(s)

704-6

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cites work

1 reference

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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7 January 2021

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

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7 January 2021

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

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7 January 2021

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

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7 January 2021

Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families.

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7 January 2021

The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene.

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7 January 2021

Absence of Linkage of Chromosome 21q21 Markers to Familial Alzheimer's Disease

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7 January 2021

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.

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7 January 2021

Genetic linkage studies in Alzheimer's disease families.

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7 January 2021

Predisposing locus for Alzheimer's disease on chromosome 21.

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7 January 2021

Genetic linkage map of human chromosome 21

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7 January 2021

A genetic linkage map of 17 markers on human chromosome 21

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7 January 2021

Linkage mapping of the highly informative DNA marker D21S156 to human chromosome 21 using a polymorphic GT dinucleotide repeat

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7 January 2021

TG repeat polymorphism at the D21S167 locus

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7 January 2021

Report of the DNA committee and catalogs of cloned and mapped genes and DNA polymorphisms.

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7 January 2021

Strategies for multilocus linkage analysis in humans

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7 January 2021

Genomic organization of the human amyloid beta-protein precursor gene

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7 January 2021

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

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7 January 2021

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type

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7 January 2021

Restriction sites containing CpG show a higher frequency of polymorphism in human DNA

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7 January 2021

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

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7 January 2021

Hydrophobic cluster analysis: an efficient new way to compare and analyse amino acid sequences

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7 January 2021

A simple method for displaying the hydropathic character of a protein

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7 January 2021

An algorithm for secondary structure determination in proteins based on sequence similarity

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7 January 2021

Structural principles of the globular organization of protein chains. A stereochemical theory of globular protein secondary structure.

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7 January 2021

Further developments of protein secondary structure prediction using information theory. New parameters and consideration of residue pairs

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7 January 2021

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

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7 January 2021