(Q28204412)

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Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

scientific article (publication date: 23 August 2002)

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9 November 2019

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system (English)

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Europe PubMed Central

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9 November 2019

phosphorylation

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Louis M. Luttrell

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9 November 2019

Robert Lefkowitz

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Robert J Lefkowitz

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9 November 2019

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A Musa Zamah

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9 November 2019

Martha Delahunty

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9 November 2019

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12 June 2002

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9 November 2019

Journal of Biological Chemistry

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9 November 2019

277

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9 November 2019

34

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9 November 2019

31249-31256

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9 November 2019

Beta-adrenergic receptors: biochemical mechanisms of physiological regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Selectivity of the .beta.-adrenergic receptor among Gs, Gi's, and Go: assay using recombinant .alpha. subunits in reconstituted phospholipid vesicles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Cardiac hypertrophy. Mechanical, neural, and endocrine dependence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Functional and structural complexity of signal transduction via G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Mammalian .beta.2-adrenergic receptor: purification and characterization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Pure β-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Expression of G-protein alpha subunits in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Recent advances in cardiac beta(2)-adrenergic signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202753200

21 January 2018

Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M202753200

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M202753200

Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M202753200

G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M202753200

A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M202753200

Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M202753200

Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M202753200

Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M202753200

Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M202753200

Identifiers

10.1074/JBC.M202753200

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12063255%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12063255%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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