(Q28201382)

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Validating survivin as a cancer therapeutic target

scientific article (publication date: 2003)

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Europe PubMed Central

Validating survivin as a cancer therapeutic target (English)

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Dario C Altieri

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Dario C Altieri

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January 2003

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Nature Reviews Cancer

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3

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1

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46-54

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Apoptosis in development

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Cell death inhibition: keeping caspases in check

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31 March 2020

CD95's deadly mission in the immune system

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31 March 2020

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

The Bcl2 family: regulators of the cellular life-or-death switch

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

IAP proteins: blocking the road to death's door

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Mechanisms of caspase activation and inhibition during apoptosis

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Cell division regulation by BIR1, a member of the inhibitor of apoptosis family in yeast.

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair.

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis.

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Characterization of XIAP-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Destabilizing influences in apoptosis: sowing the seeds of IAP destruction

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Control of apoptosis and mitotic spindle checkpoint by survivin

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Structural basis for phosphoserine-proline recognition by group IV WW domains

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Repression of CDK1 and other genes with CDE and CHR promoter elements during DNA damage-induced G(2)/M arrest in human cells

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

A p34(cdc2) survival checkpoint in cancer

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Participation of Survivin in mitotic and apoptotic activities of normal and tumor-derived cells

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Human survivin is a kinetochore-associated passenger protein

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https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34(+) cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

The antiapoptosis protein survivin is associated with cell cycle entry of normal cord blood CD34(+) cells and modulates cell cycle and proliferation of mouse hematopoietic progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Interleukin-11 up-regulates survivin expression in endothelial cells through a signal transducer and activator of transcription-3 pathway

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Chromosomal passengers and the (aurora) ABCs of mitosis

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Livin, a novel inhibitor of apoptosis protein family member

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways.

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Overexpression of TIAP/m-survivin in thymocytes enhances cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Survivin inhibition induces human neural tumor cell death through caspase-independent and -dependent pathways

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Effects of survivin antagonists on growth of established tumors and B7-1 immunogene therapy

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Ribozyme-mediated attenuation of survivin expression sensitizes human melanoma cells to cisplatin-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Deterin, a new inhibitor of apoptosis from Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Cancer gene therapy using a survivin mutant adenovirus

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Human inhibitor of apoptosis protein (IAP) survivin participates in regulation of chromosome segregation and mitotic exit

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

A role for survivin in chemoresistance of endothelial cells mediated by VEGF

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Cytokine-regulated expression of survivin in myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers.

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Expression of survivin in esophageal cancer: correlation with the prognosis and response to chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Relationship between expression of genes involved in cell cycle control and apoptosis in diffuse large B cell lymphoma: a preferential survivin–cyclin B link

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Expression and prognostic significance of survivin in de novo acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Aberrant expression of caspase cascade regulatory genes in adult T-cell leukaemia: survivin is an important determinant for prognosis

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Anti-apoptosis gene, survivin, and prognosis of neuroblastoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Survivin: a novel neuroendocrine marker for pheochromocytoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Activation of cancer-specific gene expression by the survivin promoter

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

DNA demethylase is expressed in ovarian cancers and the expression correlates with demethylation of CpG sites in the promoter region of c-erbB-2 and survivin genes

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Gene expression profile changes in initiation and progression of squamous cell carcinoma of esophagus

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

survivin messenger RNA expression is a good prognostic biomarker for oesophageal carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Tumor Content of the Antiapoptosis Molecule Survivin and Recurrence of Bladder Cancer

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Downregulation of survivin expression by induction of the effector cell protease receptor-1 reduces tumor growth potential and results in an increased sensitivity to anticancer agents in human colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Complexities in the development of cyclin-dependent kinase inhibitor drugs

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Phase I study of the cyclin-dependent kinase inhibitor flavopiridol in combination with paclitaxel in patients with advanced solid tumors.

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

LATS1 tumor suppressor regulates G2/M transition and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA.

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Control of apoptosis during angiogenesis by survivin expression in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting.

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

From bench to clinic with apoptosis-based therapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FNRC968

31 March 2020

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