(Q27684715)

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Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

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Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition (English)

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Trypanosoma cruzi

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Zdzislaw Wawrzak

5

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Silvano Tortorella

object named as

Silvano Tortorella

9

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Roberto Di Santo

object named as

Roberto Di Santo

6

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author name string

Laura Friggeri

1

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Tatiana Y Hargrove

2

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Girish Rachakonda

3

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Amanda D Williams

4

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Daniela De Vita

7

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Michael R Waterman

8

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Fernando Villalta

10

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Galina I Lepesheva

11

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publication date

14 August 2014

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Journal of Medicinal Chemistry

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57

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15

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6704-17

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Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

1 reference

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CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds

1 reference

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1 reference

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1 reference

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1 reference

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Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Structural basis for conservation in the CYP51 family

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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12 December 2020

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10.1021/JM500739F

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