(Q27552982)

English

Chromatin-silencing protein SIR4 YDR227W

fungal protein found in Saccharomyces cerevisiae S288c

SIR4
YDR227W
chromatin-silencing protein SIR4

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Statements

1 reference

25 May 2022

1 reference

19 January 2017

Sir4, SID domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

10 references

9 May 2019

Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

Multiple interactions in Sir protein recruitment by Rap1p at silencers and telomeres in yeast.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

Defining the budding yeast chromatin-associated interactome

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

A role for the nucleoporin Nup170p in chromatin structure and gene silencing

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

Domain structure and protein interactions of the silent information regulator Sir3 revealed by screening a nested deletion library of protein fragments

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions.

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

A novel role for histone chaperones CAF-1 and Rtt106p in heterochromatin silencing

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

determination method

IPI

double-stranded DNA binding

3 references

9 May 2019

Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

determination method

IDA

cell component

chromatin silencing complex

1 reference

9 May 2019

Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

determination method

IEA

chromosome, subtelomeric region

1 reference

9 May 2019

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

determination method

IEA

biological process

transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11978&geneProductId=UniProtKB:P11978

determination method

IEA

regulation of transcription, DNA-templated

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11978&geneProductId=UniProtKB:P11978

determination method

IEA

double-strand break repair via nonhomologous end joining

1 reference

9 May 2019

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

determination method

IMP

silent mating-type cassette heterochromatin assembly

3 references

9 May 2019

Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

9 May 2019

Regulating repression: roles for the sir4 N-terminus in linker DNA protection and stabilization of epigenetic states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

determination method

IGI

positive regulation of heterochromatin assembly

1 reference

9 May 2019

Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate de novo Assembly of Heterochromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11978

1 reference

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P11978

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

Saccharomyces Genome Database ID

1 reference

20 March 2022

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