(Q27552645)

Nuclear protein localization protein 4

1 reference

P-P-bond-hydrolysis-driven transporter

1 reference

Transporter Classification Database ID

3.A.16.1.2

2 October 2019

hierarchical database ID heuristic

membrane protein

1 reference

inferred from GOA cell component → membrane

Endoplasmic Reticular Retrotranslocon

1 reference

Transporter Classification Database ID

3.A.16.1.2

2 October 2019

hierarchical database ID heuristic

NPL4, zinc-binding putative, protein family

1 reference

inferred from protein domain or family

Nuclear pore localisation protein NPL4, C-terminal domain, protein family

1 reference

inferred from protein domain or family

MPN domain, protein family

1 reference

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

ubiquitin protein ligase binding

IBA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

9 references

14 February 2019

Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

14 February 2019

A comprehensive two-hybrid analysis to explore the yeast protein interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

14 February 2019

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

14 February 2019

Ubx2 links the Cdc48 complex to ER-associated protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

14 February 2019

A stress-responsive system for mitochondrial protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

14 February 2019

Key steps in ERAD of luminal ER proteins reconstituted with purified components

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

14 February 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

14 February 2019

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

14 February 2019

Functional organization of the yeast proteome by systematic analysis of protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

nuclear outer membrane-endoplasmic reticulum membrane network

cell component

1 reference

14 February 2019

The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

Cdc48p-Npl4p-Vms1p AAA ATPase complex

1 reference

14 February 2019

A stress-responsive system for mitochondrial protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

1 reference

14 February 2019

A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

VCP-NPL4-UFD1 AAA ATPase complex

Doa10p ubiquitin ligase complex

1 reference

14 February 2019

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

perinuclear region of cytoplasm

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

endoplasmic reticulum membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

Hrd1p ubiquitin ligase ERAD-L complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

endoplasmic reticulum

1 reference

14 February 2019

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33755&geneProductId=UniProtKB:P33755

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33755&geneProductId=UniProtKB:P33755

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

14 February 2019

One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

14 February 2019

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

integral component of membrane

HDA

1 reference

14 January 2019

Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33755&geneProductId=UniProtKB:P33755

40S subunit dissociation and proteasome-dependent RNA degradation in nonfunctional 25S rRNA decay

ISM

biological process

nonfunctional rRNA decay

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

cytoplasm protein quality control by the ubiquitin-proteasome system

1 reference

14 February 2019

Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

mitotic spindle disassembly

1 reference

14 February 2019

The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

negative regulation of telomerase activity

1 reference

14 February 2019

Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

mitochondria-associated ubiquitin-dependent protein catabolic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

ribosome-associated ubiquitin-dependent protein catabolic process

1 reference

14 February 2019

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

retrograde protein transport, ER to cytosol

1 reference

14 February 2019

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

ubiquitin-dependent ERAD pathway

1 reference

14 February 2019

HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

14 February 2019

The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

positive regulation of protein localization to nucleus

ER-associated misfolded protein catabolic process

ubiquitin-dependent protein catabolic process

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33755&geneProductId=UniProtKB:P33755

protein localization to vacuole

1 reference

14 February 2019

Cdc48 and ubiquilins confer selective anterograde protein sorting and entry into the multivesicular body in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33755

Nuclear pore localisation protein NPL4, C-terminal

has part(s)

1 reference

NPL4, zinc-binding putative

1 reference

MPN domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

Transporter Classification Database ID

1 reference

20 March 2022

3.A.16.1.2

2 references

Transporter Classification database

13 March 2020

Transporter Classification database