(Q27548297)

Aspartate decarboxylase-like domain superfamily

1 reference

P-loop containing nucleoside triphosphate hydrolase

1 reference

AAA ATPase, CDC48 family

1 reference

Endoplasmic Reticular Retrotranslocon

1 reference

Transporter Classification Database ID

3.A.16.1.2

2 October 2019

hierarchical database ID heuristic

ATPase, AAA-type, core domain, protein family

1 reference

CDC48, N-terminal subdomain, protein family

1 reference

AAA proteins

1 reference

CDC48, domain 2, protein family

1 reference

Vps4 oligomerisation, C-terminal domain, protein family

1 reference

ATPase, AAA-type, conserved site, protein family

1 reference

Saccharomyces cerevisiae S288c

found in taxon

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

27 March 2018

The ATPase activity of purified CDC48p from Saccharomyces cerevisiae shows complex dependence on ATP-, ADP-, and NADH-concentrations and is completely inhibited by NEM.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

ubiquitin binding

1 reference

27 March 2018

Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

1 reference

27 March 2018

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

1 reference

27 March 2018

protein binding

22 references

27 March 2018

High-quality binary protein interaction map of the yeast interactome network

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

A comprehensive two-hybrid analysis to explore the yeast protein interactome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Sel1p/Ubx2p participates in a distinct Cdc48p-dependent endoplasmic reticulum-associated degradation pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Ubx2 links the Cdc48 complex to ER-associated protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Sec61p is part of the endoplasmic reticulum-associated degradation machinery

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Functional organization of the yeast proteome by systematic analysis of protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Key steps in ERAD of luminal ER proteins reconstituted with purified components

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

The Cdc48 ATPase modulates the interaction between two proteolytic factors Ufd2 and Rad23.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

A stress-responsive system for mitochondrial protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

27 March 2018

An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

protein phosphatase regulator activity

1 reference

27 March 2018

The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7).

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

identical protein binding

1 reference

27 March 2018

Key steps in ERAD of luminal ER proteins reconstituted with purified components

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

cell component

RQC complex

1 reference

27 March 2018

A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

VCP-NPL4-UFD1 AAA ATPase complex

nucleus

1 reference

27 March 2018

Tyrosine phosphorylation regulates cell cycle-dependent nuclear localization of Cdc48p

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

1 reference

27 March 2018

mitochondrion

1 reference

27 March 2018

A stress-responsive system for mitochondrial protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

Cdc48p-Npl4p-Vms1p AAA ATPase complex

1 reference

27 March 2018

A stress-responsive system for mitochondrial protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

intracellular membrane-bounded organelle

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

1 reference

27 March 2018

cytosolic large ribosomal subunit

1 reference

27 March 2018

Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

1 reference

27 March 2018

Doa10p ubiquitin ligase complex

1 reference

27 March 2018

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

endoplasmic reticulum membrane

1 reference

27 March 2018

Pkc1p modifies CPY* degradation in the ERAD pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

cytosol

1 reference

27 March 2018

Pkc1p modifies CPY* degradation in the ERAD pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

biological process

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

1 reference

27 March 2018

ribosome-associated ubiquitin-dependent protein catabolic process

negative regulation of telomerase activity

1 reference

27 March 2018

Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

mitochondria-associated ubiquitin-dependent protein catabolic process

1 reference

27 March 2018

A stress-responsive system for mitochondrial protein degradation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

endoplasmic reticulum membrane fusion

1 reference

27 March 2018

Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

positive regulation of protein localization to nucleus

retrograde protein transport, ER to cytosol

1 reference

27 March 2018

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

cytoplasm protein quality control by the ubiquitin-proteasome system

1 reference

27 March 2018

Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

macroautophagy

1 reference

27 March 2018

Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

mitotic spindle disassembly

1 reference

27 March 2018

The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

nonfunctional rRNA decay

1 reference

27 March 2018

40S subunit dissociation and proteasome-dependent RNA degradation in nonfunctional 25S rRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

SCF complex disassembly in response to cadmium stress

1 reference

27 March 2018

Signal-induced disassembly of the SCF ubiquitin ligase complex by Cdc48/p97.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

sister chromatid biorientation

1 reference

27 March 2018

The AAA-ATPase Cdc48 and cofactor Shp1 promote chromosome bi-orientation by balancing Aurora B activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

27 March 2018

The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

positive regulation of histone H2B ubiquitination

1 reference

27 March 2018

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

nuclear protein quality control by the ubiquitin-proteasome system

1 reference

27 March 2018

The Cdc48 protein and its cofactor Vms1 are involved in Cdc13 protein degradation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

ribophagy

1 reference

27 March 2018

Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

protein transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

1 reference

27 March 2018

piecemeal microautophagy of the nucleus

1 reference

27 March 2018

Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

ATP metabolic process

1 reference

27 March 2018

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

regulation of phosphoprotein phosphatase activity

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25694&geneProductId=UniProtKB:P25694

ATPase, AAA-type, conserved site

has part(s)

1 reference

CDC48, N-terminal subdomain

1 reference

AAA+ ATPase domain

1 reference

Vps4 oligomerisation, C-terminal

1 reference

ATPase, AAA-type, core

1 reference

CDC48, domain 2

1 reference

Saccharomyces Genome Database ID

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

20 March 2022

Transporter Classification Database ID

3.A.16.1.2

2 references

Transporter Classification database

13 March 2020

Transporter Classification database