(Q24675475)

English

Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail

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Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail (English)

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CD79A antigen (immunoglobulin-associated alpha)

1 reference

GOA release 2020-03-11

phosphorylation

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based on heuristic

inferred from title

object named as

K Rajewsky

8

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Michel C. Nussenzweig

7

object named as

M C Nussenzweig

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author name string

M Kraus

1

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L I Pao

2

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A Reichlin

3

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Y Hu

4

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B Canono

5

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J C Cambier

6

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language of work or name

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publication date

20 August 2001

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Journal of Experimental Medicine

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194

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4

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455-69

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The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

CD22 is a negative regulator of B-cell receptor signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

Hyperresponsive B cells in CD22-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

Adaptors and molecular scaffolds in immune cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

RAG-1-deficient mice have no mature B and T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

Inducible gene targeting in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

7 April 2017

B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

T-Independent immune response: new aspects of B cell biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Monomeric and oligomeric complexes of the B cell antigen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Development and function of B-1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

B cells are programmed to activate kappa and lambda for rearrangement at consecutive developmental stages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

B cell development: signal transduction by antigen receptors and their surrogates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Positive versus negative signaling by lymphocyte antigen receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

A tyrosine-based signal present in Ig alpha mediates B cell receptor constitutive internalization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Regulation of ITAM signaling by specific sequences in Ig-beta B cell antigen receptor subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Clonal selection and learning in the antibody system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

The alpha/beta sheath and its cytoplasmic tyrosines are required for signaling by the B-cell antigen receptor but not for capping or for serine/threonine-kinase recruitment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

BLyF, a novel cell-type- and stage-specific regulator of the B-lymphocyte gene mb-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Cooperativity and segregation of function within the Ig-alpha/beta heterodimer of the B cell antigen receptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Defective B cell development and function in Btk-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

Different patterns of calcium signaling triggered through two components of the B lymphocyte antigen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 September 2017

CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

30 May 2018

Syk tyrosine kinase and B cell antigen receptor (BCR) immunoglobulin-alpha subunit determine BCR-mediated major histocompatibility complex class II-restricted antigen presentation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

30 May 2018

The immunoglobulin (Ig)alpha and Igbeta cytoplasmic domains are independently sufficient to signal B cell maturation and activation in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

30 May 2018

Antigen presentation by the B cell antigen receptor is driven by the alpha/beta sheath and occurs independently of its cytoplasmic tyrosines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

30 May 2018

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

30 May 2018

Impaired expansion of mouse B cell progenitors lacking Btk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

30 May 2018

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

30 May 2018

Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

30 May 2018

CD22 regulates thymus-independent responses and the lifespan of B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

19 June 2018

Antigen receptor tail clue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

19 June 2018

Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.194.4.455

21 January 2018

Punctuated evolution caused by selection of rare beneficial mutations.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.194.4.455

21 January 2018

CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.194.4.455

21 January 2018

Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.194.4.455

21 January 2018

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.194.4.455

21 January 2018

Antigen receptor signaling gives lymphocytes a long life

1 reference

https://api.crossref.org/works/10.1084%2FJEM.194.4.455

21 January 2018

Ig-α Cytoplasmic Truncation Renders Immature B Cells More Sensitive to Antigen Contact

1 reference

https://api.crossref.org/works/10.1084%2FJEM.194.4.455

21 January 2018

Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling

1 reference

https://api.crossref.org/works/10.1084%2FJEM.194.4.455

21 January 2018

Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 November 2018

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 November 2018

Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 November 2018

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193498

28 November 2018

A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential signaling through the Ig-alpha and Ig-beta components of the B cell antigen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

2 references

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

https://api.crossref.org/works/10.1084%2FJEM.194.4.455

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphopeptide-binding specificity of Src family SH2 domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive selection of natural autoreactive B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of Ig beta in precursor B cell transition and allelic exclusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A negative regulatory role for Ig-alpha during B cell development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk

1 reference

https://pubmed.ncbi.nlm.nih.gov/11514602

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1084/JEM.194.4.455

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