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Pharmacology of nociceptin and its receptor: a novel therapeutic target

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Europe PubMed Central

Pharmacology of nociceptin and its receptor: a novel therapeutic target (English)

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G Calo'

1

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R Guerrini

2

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A Rizzi

3

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S Salvadori

4

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D Regoli

5

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publication date

April 2000

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British Journal of Pharmacology

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129

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7

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1261-83

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Agonistic effect of buprenorphine in a nociceptin/OFQ receptor-triggered reporter gene assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Nocistatin, a peptide that blocks nociceptin action in pain transmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Ligands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

8-acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as orphanin FQ receptor agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Comparison of the effects of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

The orphan opioid receptor and its endogenous ligand--nociceptin/orphanin FQ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Expression of alternate forms of brain opioid 'orphan' receptor mRNA in activated human peripheral blood lymphocytes and lymphocytic cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

Cloning of a delta opioid receptor by functional expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

7 April 2017

[Phe1psi(CH2-NH)Gly2]nociceptin-(1 - 13)-NH2 activation of an inward rectifier as a partial agonist of ORL1 receptors in rat periaqueductal gray.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Further characterization of the ORL1 receptor-mediated inhibition of noradrenaline release in the mouse brain in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Strain-dependent effects of supraspinal orphanin FQ/nociceptin on thermal nociceptive sensitivity in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Anti-nociceptive responses produced by human putative counterpart of nocistatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

[Phe1psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 is an agonist of the nociceptin (ORL1) receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Endogenous orphanin FQ: evidence for a role in the modulation of electroacupuncture analgesia and the development of tolerance to analgesia produced by morphine and electroacupuncture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Naloxone-insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by the novel opioid, nociceptin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

A potent and selective endogenous agonist for the mu-opiate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Diuretic and antinatriuretic responses produced by the endogenous opioid-like peptide, nociceptin (orphanin FQ).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

International Union of Pharmacology. XII. Classification of opioid receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Nociceptin induced inhibition of K+ evoked glutamate release from rat cerebrocortical slices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

The physiology and brain mechanisms of feeding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Glutamate, GABA and epilepsy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Increase by the ORL1 receptor (opioid receptor-like1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Primary structure and tissue distribution of the orphanin FQ precursor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Molecular cloning and functional expression of a mu-opioid receptor from rat brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

cDNA cloning and regional distribution of a novel member of the opioid receptor family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

cDNA cloning of an orphan opiate receptor gene family member and its splice variant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned mu, delta, and kappa opioid receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Structure and chromosomal mapping of genes for the mouse kappa-opioid receptor and an opioid receptor homologue (MOR-C).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. IX. Recommendations on terms and symbols in quantitative pharmacology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Conformationally restricted analogs of somatostatin with high mu-opiate receptor specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Opiate reward: sites and substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antogonist potencies of narcotic analgesics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Structure-activity relationship studies on the novel neuropeptide orphanin FQ.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 September 2017

The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Pharmacological characterization of the nociceptin receptor mediating hyperphagia: identification of a selective antagonist.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Characterization of [Nphe(1)]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Nociceptin and the ORL-1 ligand [Phe1psi (CH2-NH)Gly2]nociceptin(1-13)NH2 exert anti-opioid effects in the Freund's adjuvant-induced arthritic rat model of chronic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Orphanin FQ/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Inhibition of cardiovascular activity following microinjection of novel opioid-like neuropeptide nociceptin (orphanin FQ) into the rat rostral ventrolateral medulla

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Activation of an inwardly rectifying K+ conductance by orphanin-FQ/nociceptin in vasopressin-containing neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Biotransformation of nociceptin/orphanin FQ by enzyme activity from morphine-naive and morphine-treated cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Orphanin-FQ/nociceptin (OFQ/N) modulates the activity of suprachiasmatic nucleus neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Cloning, expression and functional role of a nociceptin/orphanin FQ receptor in the porcine gastrointestinal tract

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Nociceptin, a novel endogenous ligand for the ORL1 receptor, dilates isolated resistance arteries from the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Evidence that [Phe1 psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2, a peripheral ORL-1 receptor antagonist, acts as an agonist in the rat spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Nociceptin/orphanin FQ. A new opioid, a new analgesic?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

ORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Distribution of prepro-nociceptin/orphanin FQ mRNA and its receptor mRNA in developing and adult mouse central nervous systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Nociceptin fails to affect heroin self-administration in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Inhibition of nociceptin on sensory neuropeptide release and mast cell-mediated plasma extravasation in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Inhibition of rat oxytocin and vasopressin supraoptic nucleus neurons by nociceptin in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Nociceptin hyperpolarises neurones in the rat ventromedial hypothalamus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

A new selective antagonist of the nociceptin receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, in the rat formalin test

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Prejunctional modulation by nociceptin of nerve-mediated inotropic responses in guinea-pig left atrium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Inhibition by nociceptin of neurogenic inflammation and the release of SP and CGRP from sensory nerve terminals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Modulation of excitatory synaptic transmission by nociceptin in superficial dorsal horn neurones of the neonatal rat spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Characterization of nociceptin hyperalgesia and allodynia in conscious mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Orphanin FQ inhibits synaptic transmission and long-term potentiation in rat hippocampus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by carageenan injection into the rat paw.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Effects of sigma ligands on the nociceptin/orphanin FQ receptor co-expressed with the G-protein-activated K+ channel in Xenopus oocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Orphanin FQ, agonist of orphan opioid receptor ORL1, stimulates feeding in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: its involvement in allodynic response to innocuous stimulus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Nociceptin stimulates locomotion and exploratory behaviour in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Orphanin FQ is a functional anti-opioid peptide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Nociceptin (orphanin FQ), an endogenous ligand for the QRL1 (opioid-receptor-like1) receptor; modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Intracerebroventricular orphanin FQ/nociceptin suppresses dopamine release in the nucleus accumbens of anaesthetized rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Depression of glutamatergic transmission by nociceptin in the neonatal rat hemisected spinal cord preparation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

The mouse vas deferens: a pharmacological preparation sensitive to nociceptin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Cloning and expression of a cDNA encoding a mouse brain orphanin FQ/nociceptin precursor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Structure and regional distribution of nociceptin/orphanin FQ precursor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Dynorphin1–8 and dynorphin1–9 are ligands for the κ-subtype of opiate receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Bimorphinans as highly selective, potent kappa opioid receptor antagonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Molecular mechanism of opioid receptor selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

[3H]U-69593 a highly selective ligand for the opioid kappa receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Irreversible opiate agonists and antagonists: V. Hydrazone and acylhydrazone derivatives of naltrexone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Tachykinins and calcitonin gene-related peptide as co-transmitters in local motor responses produced by sensory nerve activation in the guinea-pig isolated renal pelvis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

30 May 2018

Reverse physiology: discovery of the novel neuropeptide, orphanin FQ/nociceptin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0703219

21 January 2018

Modulation of 5-hydroxytryptamine efflux from rat cortical synaptosomes by opioids and nociceptin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Multiple sites of action in the inhibitory effect of nociceptin on the micturition reflex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

[Nphe(1)]nociceptin-(1-13)-NH(2) antagonizes nociceptin effects in the mouse colon.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

L-glutamate and gamma-aminobutyric acid efflux from rat cerebrocortical synaptosomes: modulation by kappa- and mu- but not delta- and opioid receptor like-1 receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Inhibitory effect of nociceptin on [3H]-5-HT release from rat cerebral cortex slices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Pharmacological properties of TRK-820 on cloned mu-, delta- and kappa-opioid receptors and nociceptin receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Orphanin FQ, a novel neuropeptide with anti-stress-like activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Nociceptin/orphanin FQ dilates pial arteries by K(ATP) and K(ca) channel activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Effects of orphanin FQ on endomorphin-1 induced analgesia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Orphanin FQ/nociceptin blocks acquisition of morphine place preference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Orphanin FQ and behavioral sensitization to cocaine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Nociceptin system plays a role in the memory retention: involvement of naloxone benzoylhydrazone binding sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Pre- and postsynaptic actions of opioid and orphan opioid agonists in the rat arcuate nucleus and ventromedial hypothalamus in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Modulation of vestibular function by nociceptin/orphanin FQ: an in vivo and in vitro study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Nociceptin receptor activation inhibits tachykinergic non adrenergic non cholinergic contraction of guinea pig isolated bronchus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Limbic seizures increase pronociceptin mRNA levels in the thalamic reticular nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Characterization of nociceptin receptors in the periphery: in vitro and in vivo studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

In vivo metabolism of nociceptin/orphanin FQ in rat hippocampus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Effects of nocistatin on nociceptin-induced impairment of learning and memory in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Functional blockade of opioid analgesia by orphanin FQ/nociceptin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Effect of nociceptin on alcohol intake in alcohol-preferring rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

The stereoselective kappa-opioid receptor antagonist Mr 2266 does not exhibit stereoselectivity as an antagonist at the orphan opioid (ORL1) receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

The nociceptin receptor-mediated inhibition of the rat rostral ventrolateral medulla neurons in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Nociceptin inhibits noradrenaline release in the mouse brain cortex via presynaptic ORL1 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to nociceptin/orphanin FQ.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Identification and differential regional expression of KOR-3/ORL-1 gene splice variants in mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Orphanin FQ/nociceptin inhibits synaptic transmission and long-term potentiation in rat dentate gyrus through postsynaptic mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

The inhibitory effect of nociceptin on the micturition reflex in anaesthetized rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Structure−Activity Study of the Nociceptin(1−13)-NH2N-Terminal Tetrapeptide and Discovery of a Nociceptin Receptor Antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

[Phe1psi(CH2-NH)Gly2]-nociceptin-(1-13)NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Pharmacological studies on the "orphan" opioid receptor in central and peripheral sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Nociceptin-induced inhibition of tachykinergic neurotransmission in guinea pig bronchus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Modification of dopamine release by nociceptin in conscious rat striatum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Orphanin FQ has an inhibitory effect on the guinea pig ileum and the mouse vas deferens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Effect of nociceptin on heart rate and blood pressure in anaesthetized rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Pharmacological characterization of nociceptin receptor: an in vitro study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Nociceptin/orphanin FQ and opioid peptides show overlapping distribution but not co-localization in pain-modulatory brain regions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Inhibition by nociceptin of the light-evoked release of ACh from retinal cholinergic neurones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Orphan neuropeptide NocII, a putative pronociceptin maturation product, stimulates locomotion in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Injections of nociceptin into nucleus accumbens shell or ventromedial hypothalamic nucleus increase food intake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Antagonistic action of orphanin FQ on acupuncture analgesia in rat brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Nociceptin: an endogenous agonist for central opioid like1 (ORL1) receptors possesses systemic vasorelaxant properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Modulation of voltage-gated calcium channels by orphanin FQ in freshly dissociated hippocampal neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Immunohistochemical localization of ORL-1 in the central nervous system of the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571975

28 November 2018

Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin/orphanin FQ increases blood pressure and heart rate via sympathetic activation in sheep

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal analgesic activity of orphanin FQ/nociceptin and its fragments

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orphanin FQ potentiates formalin-induced pain behavior and antagonizes morphine analgesia in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Phe1psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 acts as an agonist of the orphanin FQ/nociceptin receptor in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further Studies on Nociceptin-Related Peptides: Discovery of a New Chemical Template with Antagonist Activity on the Nociceptin Receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of [Tyr1]nociceptin analogs: receptor binding and bioassay studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin or antinociceptin: potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure–activity studies on nociceptin/orphanin FQ: from full agonist, to partial agonist, to pure antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antinociceptive effects of the ORL1 receptor agonist nociceptin/orphanin FQ in diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central administration of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)-NH2 and orphanin FQ/nociceptin (OFQ/N) produce similar cardiovascular and renal responses in conscious rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-hyperalgesic and anti-allodynic effects of intrathecal nociceptin/orphanin FQ in rats after spinal cord injury, peripheral nerve injury and inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not inhibited by naloxone in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of activity for nociceptin in the mouse vas deferens

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin, an endogenous ligand for the ORL1 receptor, has novel hypotensive activity in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin protects capsaicin-sensitive afferent fibers in the rat urinary bladder from desensitization

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of cross-tolerance between the antinociceptive effect of intrathecal orphanin FQ and morphine in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional significance of a newly discovered neuropeptide, orphanin FQ, in rat gastrointestinal motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin, a novel endogenous ligand for the ORL1 receptor, has potent erectile activity in the cat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Phe1phi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 acts as a partial agonist at ORL1 receptor endogenously expressed in mouse N1E-115 neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pronociceptive effects of the neuropeptide, nociceptin, in the land snail, Cepaea nemoralis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Supraspinal hyperalgesia and spinal analgesia by [Phe1psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 in rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tolerance develops to the inhibitory effect of orphanin FQ on morphine-induced antinociception in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of nociceptin, an endogenous ligand for the ORL1 receptor, on rat colonic contraction and transit

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral and central actions of orphanin FQ (nociceptin) on murine colon

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiovascular effects of nociceptin in unanesthetized mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinally delivered nociceptin/orphanin FQ reduces flinching behaviour in the rat formalin test

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin in vitro biotransformation in human blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analgesic activity of orphanin FQ2, murine prepro-orphanin FQ141-157 in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naloxone benzoylhydrazone (NalBzoH) analgesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orphanin FQ: receptor binding and analog structure activity relationships in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery

1 reference

https://pubmed.ncbi.nlm.nih.gov/10742280

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The orphan opioid receptor and its endogenous ligand — nociceptin/orphanin FQ

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0703219

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.BJP.0703219

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

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