(Q24649052)

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Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding

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Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding (English)

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protein heterodimerization activity

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based on heuristic

inferred from title

author name string

F C Stomski

1

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Q Sun

2

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C J Bagley

3

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J Woodcock

4

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G Goodall

5

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R K Andrews

6

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M C Berndt

7

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A F Lopez

8

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language of work or name

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publication date

June 1996

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Molecular and Cellular Biology

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16

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6

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3035-46

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Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130

1 reference

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LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor

1 reference

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7 April 2017

Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling

1 reference

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7 April 2017

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region

1 reference

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7 April 2017

Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF

1 reference

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7 April 2017

A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231298

7 April 2017

Molecular cloning and expression of an IL-6 signal transducer, gp130

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231298

7 April 2017

Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors

1 reference

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7 April 2017

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor

1 reference

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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

1 reference

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Signal transduction by receptors with tyrosine kinase activity

1 reference

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Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling

1 reference

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IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase

1 reference

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Subunit promiscuity among hemopoietic growth factor receptors

1 reference

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Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines

1 reference

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7 April 2017

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231298

7 April 2017

Evidence for the ligand-induced conversion from a dimer to a tetramer of the granulocyte colony-stimulating factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231298

7 April 2017

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231298

7 April 2017

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1 reference

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Structural design and molecular evolution of a cytokine receptor superfamily

1 reference

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7 April 2017

A model for the interaction of the GM-CSF, IL-3 and IL-5 receptors with their ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231298

28 September 2017

Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.

1 reference

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Activation and inhibition of erythropoietin receptor function: role of receptor dimerization

1 reference

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Multimeric cytokine receptors: common versus specific functions

1 reference

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A low affinity chimeric human alpha/beta-granulocyte-macrophage colony-stimulating factor receptor induces ligand-dependent proliferation in a murine cell line.

1 reference

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Dimerization of cell surface receptors in signal transduction

1 reference

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Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling

1 reference

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28 September 2017

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1 reference

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Interleukin-3 signals through multiple isoforms of Stat5.

1 reference

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The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration

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The human hematopoietic colony-stimulating factors

1 reference

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The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1 reference

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Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release

1 reference

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28 September 2017

GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells.

1 reference

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1 reference

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Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist

1 reference

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Human granulocyte-macrophage colony-stimulating factor receptor signal transduction requires the proximal cytoplasmic domains of the alpha and beta subunits.

1 reference

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A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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10.1128/MCB.16.6.3035

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